花椒肉桂酸甲酯对运动性骨骼肌损伤的保护作用及其作用机制  

Protective Effects and Mechanism of Sichuan Peppercorn Methyl Cinnamate on Exercise-induced Skeletal Muscle Damage

作　　者：李鸿龙 Li Honglong(Faculty of Health Sciences and Sports,Macao Polytechnic University,Macao,999078,China)

机构地区：[1]澳门理工大学健康科学及体育学院,中国澳门999078

出　　处：《分子植物育种》2023年第17期5802-5808,共7页Molecular Plant Breeding

摘　　要：本研究旨在研究花椒中天然存在的酯类有机物肉桂酸甲酯对运动性骨骼肌损伤的保护作用及其作用机制。通过使用运动性骨骼肌损伤模型大鼠,观察了肉桂酸甲酯对血清炎症因子、骨骼肌氧化应激指标、骨骼肌形态、线粒体呼吸链复合物活性以及AMPK通路相关蛋白的影响。研究结果显示,肉桂酸甲酯能够降低炎症因子水平、减轻氧化应激反应、改善骨骼肌形态、提高线粒体呼吸链复合物活性,并激活AMPK通路。因此,肉桂酸甲酯可能通过激活AMPK通路改善骨骼肌线粒体功能,从而对运动性骨骼肌损伤具有保护作用。本研究结果为肉桂酸甲酯作为治疗运动性骨骼肌损伤的天然药物提供了科学依据。This study aimed to investigate the protective effects and underlying mechanism of Sichuan peppercorn methyl cinnamate,a natural ester compound found in Sichuan peppercorn,on exercise-induced skeletal muscle damage.Using an exercise-induced skeletal muscle damage model in rats,the effects of methyl cinnamate on serum inflammatory cytokines,skeletal muscle oxidative stress markers,muscle morphology,mitochondrial respiratory chain complex activity,and AMPK pathway-related proteins were observed.The results demonstrated that methyl cinnamate reduced the levels of inflammatory cytokines,alleviated oxidative stress,improved skeletal muscle morphology,increased mitochondrial respiratory chain complex activity,and activated the AMPK pathway.Therefore,methyl cinnamate may protect against exercise-induced skeletal muscle damage by improving mitochondrial function through AMPK pathway activation.These findings provide scientific evidence for the potential use of methyl cinnamate as a natural therapeutic agent for treating exercise-induced skeletal muscle damage.

关 键 词：花椒(Zanthoxylum bungeanum) 肉桂酸甲酯 运动性骨骼肌损伤 炎症因子 氧化应激 

分 类 号：R285.5[医药卫生—中药学]