低氧预处理间充质干细胞来源外泌体的应用进展  

Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes

作　　者：卓海涛 张浩群 赵贵芳 ZHUO Haitao;ZHANG Haoqun;ZHAO Guifang(The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital,Qingyuan 511518,China;Department of Pathology,Jilin Medical University,Jilin 130013,China)

机构地区：[1]广州医科大学附属第六医院,清远市人民医院,广东清远511518 [2]吉林医药学院病理学教研室,吉林吉林130013

出　　处：《中国病理生理杂志》2023年第8期1522-1528,共7页Chinese Journal of Pathophysiology

基　　金：广东省中医药局科研项目(No.20231411);吉林省科技厅项目(No.20210101216JC);清远市科技计划项目(No.2022KJJH026);广州医科大学2023-2024年度大学生科技创新项目(No.2022A144)。

摘　　要：间充质干细胞(mesenchymal stem cells,MSCs)是一种具有自我更新和分化特性的多能细胞,分布于人体许多部位,包括骨髓、脂肪组织、牙髓、脐带和胎盘等。干细胞疗法已经在许多临床前研究中得到了很好的证明,但其植入率低、植入副作用多的弱点促使人们寻找改进方法。Mesenchymal stem cells(MSCs)primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells,thus exerting their therapeutic effects.In recent years,hypoxic preconditioning,as a novel MSC culture mode,has emerged as a research hotspot.Many previous studies have shown the role and underlying regulatory mechanisms of hypoxic preconditioning in various diseases,which has provided sufficient reference materials for the MSC research field.Therefore,this review summarizes the progress in application of hypoxiapreconditioned MSC-derived exosomes that substantially increases and improves the biological activity of specific molecules,such as microRNA.

关 键 词：低氧预处理 间充质干细胞 外泌体 微小RNA 

分 类 号：R54[医药卫生—心血管疾病] R741[医药卫生—内科学]