骨髓移植患者血流混合感染阿萨希毛孢子菌及棒状大孢酵母1例  

A case of mixed bloodstream infection of Trichosporon asahii and Magnusiomyces clavatus in a patient with bone marrow transplantation

作　　者：李继霞 闵彦 LI Jixia;MIN Yan(Department of Laboratory Medicine,The 960th Hospital of PLA,Jinan 250031,China)

机构地区：[1]解放军第九六〇医院检验科,济南250031

出　　处：《中国真菌学杂志》2023年第4期340-343,共4页Chinese Journal of Mycology

摘　　要：患者,女,40岁,患骨髓增生异常综合征。患者骨髓移植术后,反复发热,血培养显示,血流混合感染2株真菌。18S核糖体RNA(18S rRNA)测序结果显示,其中1株真菌为阿萨希毛孢子菌,另1株真菌为棒状大孢酵母。两株真菌为罕见真菌,均对伏立康唑敏感。因鉴定及药敏时间较长,患者未等调整合理抗真菌药物,因持续中性粒细胞缺乏及真菌血症死亡。该病例是国内首次报道血液病患者血流混合感染阿萨希毛孢子菌和棒状大孢酵母。A 40-year-old female patient with myelodysplastic syndrome had recurrent feveRafteRbone marrow transplantation.Blood culture showed that the bloodstream was infected with 2 strains of fungi.18S ribosomal RNA(18S rRNA)sequencing results showed that one of the fungi was Trichosporon assahii and the otheRwas Magnusiomyces clavatus.The two fungi were rare fungi,both sensitive to voriconazole.Due to the long time of identification and drug sensitivity,the patient did not wait foRthe adjustment of reasonable antifungal drugs,and died due to persistent neutropenia and fungemia.This case was the first report in Chinese of bloodstream mixed infection of Trichosporon asahii and Magnusiomyces clavatus in patients with hematological diseases.

关 键 词：阿萨希毛孢子菌 棒状大孢酵母 血液病患者 罕见真菌 快速诊断 

分 类 号：R519.8[医药卫生—内科学]