两性霉素B成功治疗不规则毛霉引起的皮肤慢性毛霉病1例  

A case of chroniccutaneous mucormycosis caused by MucoRirregulari treated with conventional amphotericin B

作　　者：王诗琪 宋营改[1] 莫然[1] 万喆[1] 徐永豪[2] 李若瑜[1] WANG Shiqi;SONG Yinggai;MO Ran;WAN Zhe;XU Yonghao;LI Ruoyu(Department of Dermatology,Peking University First Hospital,National Clinical Research Center for Skin and Im-mune Diseases,Research Center for Medical Mycology,Peking University,Beijing Key Laboratory of Molecular Diag-nosis of Dermatoses,NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics,Beijing 100034,China;Department of Dermatology,Qilu Hospital of Shandong University,Ji’nan 250063,China)

机构地区：[1]北京大学第一医院皮肤性病科真菌室,国家皮肤与免疫疾病临床医学研究中心,北京大学真菌和真菌病研究中心,皮肤病分子诊断北京市重点实验室,国家药品监督管理局化妆品质量控制与评价重点实验室,北京100034 [2]山东大学齐鲁医院皮肤科,济南250063

出　　处：《中国真菌学杂志》2023年第4期347-349,353,共4页Chinese Journal of Mycology

基　　金：“十三五”科技重大专项题(2018ZX10712001)。

摘　　要：患者,女,44岁,面部红斑、丘疹16年,溃疡、结痂8年。皮肤科检查:面部弥漫肿胀性红斑、大片状境界清晰的溃疡和坏死性焦痂。双眼睑外翻,右眼失明。真菌直接镜检、培养及分子生物学菌种鉴定,确诊为不规则毛霉所导致的皮肤慢性毛霉病,予两性霉素B静脉滴注治疗,皮损明显改善,遗留萎缩性瘢痕。The patient was a 44-year-old female with erythema and papules on heRface foR16 years,ulcers and black crusts foR8 years.Dermatological examination:diffuse swelling erythema,large well-demarcated ulcers with necrotic eschaRon heRface.She presented bilateral eyelid ectropion and lost heRsight of the right eye.The patient was diagnosed as chronic cutaneous mucormycosis caused by MucoRirregulari afteRdirect microscopic examination,fungal culture and moleculaRidentification.Intravenous amphotericin B was given.The lesions were significantly improved but left atrophic scar.

关 键 词：两性霉素B 不规则毛霉 皮肤毛霉病 

分 类 号：R519.8[医药卫生—内科学]