养心颗粒的制备及成型工艺的优化  

Preparation of Yangxin granules and optimization of the forming process

作　　者：江涛 周颐 王璐璐 JIANG Tao;ZHOU Yi;WANG Lulu(Department of Pharmacy,the Second Affiliated Hospital of the Army Medical University,Chongqing,400037 P.R.China;School of Pharmacy,Chongqing Medical University,Chongqing,401331 P.R.China)

机构地区：[1]陆军军医大学第二附属医院药学部,重庆400037 [2]重庆医科大学药学院,重庆401331

出　　处：《华西药学杂志》2023年第4期366-370,共5页West China Journal of Pharmaceutical Sciences

基　　金：重庆市科卫联合项目(ZY201802118)。

摘　　要：目的优选养心颗粒的制备工艺。方法将养心浸膏粉与辅料按1∶1混合制得养心颗粒,以相对均齐度指数、松密度、振实密度等10项物理属性指标,优选最佳辅料;以成型率、休止角、水分为评价指标,采用正交试验优选最佳制粒工艺;测定养心颗粒的临界相对湿度。结果最佳成型工艺为浸膏粉与预胶化淀粉以6∶4的比例混合,90%乙醇为润湿剂,制得颗粒的平均收率为98.57%,临界相对湿度为74%。结论文中优选出的养心颗粒制备工艺稳定可行。OBJECTIVE To optimize the preparation process of Yangxin granules.METHODS Yangxin granules were prepared by mixing the powder of Yangxin extraction pastes and excipients at 1∶1,and the best excipients were selected by 10 physical property indexes,such as relative homogeneity index,bulk density and vibrating density.The orthogonal setting test was conducted to select the best granulation process by using molding rate,resting angle and moisture as evaluation indexes,and the critical relative humidity of Yangxin granules was determined.RESULTS The optimal forming process was to mix the powder of extraction pastes with pregelatinized starch in the ratio of 6∶4 and 90%ethanol solution as wetting agent,and the average yield of the granules obtained was 98.57%and the critical relative humidity was 74%.CONCLUSION The preparation process for Yangxin granules which was preferably selected is stable and feasible.

关 键 词：养心颗粒 中药制剂 物理指纹谱 制粒工艺 正交实验 成型工艺 预胶化淀粉 临界相对湿度 

分 类 号：R94[医药卫生—药剂学]