奥美沙坦酯片联合苯磺酸氨氯地平片或络活喜治疗原发性高血压的比较观察  

Comparison of olmesartan medoxomil tablets combined with amlodipine besylate tablets or norvasc in the treatment of primary hypertension

作　　者：苏峰祥 杨景 唐春梅 杨帆 SU Feng-xiang;YANG Jing;TANG Chun-mei;YANG Fan(Department of Cardiology,Zhanjiang First Hospital of Traditional Chinese Medicine,Zhanjiang 524043,China)

机构地区：[1]湛江市第一中医医院心内科,广东湛江524043

出　　处：《广东医科大学学报》2023年第4期440-443,共4页Journal of Guangdong Medical University

基　　金：湛江市科技计划项目(2021B01134)。

摘　　要：目的了解奥美沙坦酯片分别联合苯磺酸氨氯地平片或络活喜治疗原发性高血压(PH)的效果及异同。方法112例PH患者随机分为观察组和对照组,每组56例。对照组采用国家集中采购奥美沙坦酯片联合络活喜治疗,观察组采用国家集中采购的奥美沙坦酯片和苯磺酸氨氯地平片治疗。对比两组的疗效、血压指标、成本-效果、不良反应和服药依从性。结果两组患者疗效的差异无统计学意义(P>0.05)。两组治疗后的24 h平均舒张压、24 h平均收缩压、日间平均舒张压、日间平均收缩压、夜间平均舒张压、夜间平均收缩压、舒张压节律昼夜、昼夜收缩压节律、不良反应发生率的差异均无统计学意义(P>0.05)。对照组的成本-效果比是观察组的2.6倍。观察组的中文版8条目Morisky服药依从性量表评分明显高于对照组(P<0.01)。结论国家集中采购奥美沙坦酯片联合国家集中采购苯磺酸氨氯地平片治疗PH的疗效确切,也不增加不良反应,还可降低药物费用负担和增加服药依从性。Objective To investigate the effect of olmesartan medoxomil tablets combined with amlodipine besylate tablets and norvasc in the treatment of primary hypertension(PH)as well as similarities and differences.Methods A total of 112 PH patients were randomized to the Observation Group and Control Group,56 cases in each group.The Control Group was treated with olmesartan medoxomil tablets(purchased via centralized procurement organized by the State)combined with norvasc while the Observation Group was treated with olmesartan medoxomil tablets combined with amlodipine besylate tablets(purchased via centralized procurement organized by the State).The curative effect,blood pressure indexes,cost-effectiveness,adverse reactions and medication adherence were compared between the two groups.Results There was no significant difference in efficacy between the two groups(P>0.05).There were no significant differences between the two groups in 24 h mean DBP,24 h mean SBP,daytime mean DBP,daytime mean SBP,nighttime mean DBP,nighttime mean SBP,circadian rhythm of DBP,circadian rhythm of SBP and the incidence of adverse reactions after treatment(P>0.05).The cost-effectiveness ratio of the Control Group was 2.6 times that of the Observation Group.The 8-item Morisky Medication Adherence Scale of the Observation Group was significantly higher than that of the Control Group(P<0.01).Conclusion Olmesartan medoxomil tablets(purchased via centralized procurement organized by the State)combined with amlodipine besylate tablets(purchased via centralized procurement organized by the State)has a definite effect in the treatment of PH,without increasing the incidence of adverse reactions.It can also reduce drug cost burden and increase medication adherence.

关 键 词：奥美沙坦酯 苯磺酸氨氯地平 国家集中采购 原发性高血压 对比研究 

分 类 号：R972[医药卫生—药品]