连续性肾脏替代治疗重症急性肾功能衰竭的临床疗效  

Effect of continuous renal replacement therapy on severe acute renal failure

作　　者：仲烨 张建 焦慧玲 ZHONG Ye;ZHANG Jian;JIAO Huiling(Critical care medicine,Beihai Hospital of Yantai,Yantai,Shandong,265701,China;ICU,Beihai Hospital of Yantai,Yantai,Shandong,265701,China)

机构地区：[1]烟台市北海医院重症医学科,山东烟台265701 [2]烟台市北海医院ICU,山东烟台265701

出　　处：《当代医学》2023年第7期156-158,共3页Contemporary Medicine

摘　　要：目的探讨连续性肾脏替代疗法(CRRT)治疗重症急性肾功能衰竭患者的临床效果。方法选取2018年1月至2021年5月本院收治的80例重症急性肾功能衰竭患者作为研究对象,随机分为参照组与实验组,各40例。参照组采用间歇性血液透析方法治疗,实验组采用CRRT方法治疗,比较两组临床疗效、急性生理功能和慢性健康状况评分系统Ⅱ(APACHEⅡ)、肾功能指标[尿素氮(BUN)、肌酐(SCr)、肌酐清除率(Ccr)]。结果实验组治疗总有效率(95.00%)高于参照组(72.50%),差异有统计学意义(P<0.05)。治疗前,两组APCHEⅡ评分比较差异无统计学意义;治疗后,两组APCHEⅡ评分均低于治疗前,且实验组低于参照组,差异有统计学意义(P<0.05)。治疗前,两组BUN、SCr、Ccr比较差异无统计学意义;治疗后,两组BUN、SCr水平均低于治疗前,Ccr高于治疗前,且实验组BUN、SCr水平低于参照组,Ccr高于参照组,差异有统计学意义(P<0.05)。结论CRRT治疗重症急性肾功能衰竭患者效果显著,可有效改善患者病情及肾功能,提升预后效果,值得临床推广应用。Objective To investigate the clinical effect of continuous renal replacement therapy(CRRT)in the treatment of patients with severe acute renal failure.Methods A total of 80 patients with severe acute renal failure admitted to our hospital from January 2018 to May 2021 were selected as research subjects,and they were randomly divided into the control group and the experimental group,with 40 cases in each group.The control group was treated with intermittent hemodialysis treatment,and the experimental group was treated with CRRT treatment,the clinical efficacy,acute physiology and chronic health evaluationⅡ(APACHEⅡ),renal function indexes(blood urea nitrogen[BUN],serum creatinine[SCr],and creatinine clearance rate[Ccr])were compared between two groups.Results The total effective rate of the experimental group(95.00%)was higher than that of the control group(72.50%),and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in APCHEⅡscores between the two groups;after treatment,the APCHEⅡscore of the two groups was lower than before treatment,and the experimental group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in BUN,SCr and Ccr between the two groups;after treatment,the BUN,SCr level in two groups were lower than those before treatment,Ccr was higher than before treatment,and the experimental group BUN,SCr level were lower than those in the control group,Ccr was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion CRRT is effective in the treatment of patients with severe acute renal failure,it can effectively improve the condition and kidney function of patients and improve the prognosis,it is worthy of clinical application.

关 键 词：重症急性肾功能衰竭 连续性肾脏替代疗法治疗 间歇性血液透析 疗效 急性生理功能和慢性健康状况评分系统Ⅱ评分 肾功能 

分 类 号：R692.5[医药卫生—泌尿科学]