枯草杆菌二联活菌颗粒联合茵栀黄颗粒对中轻度新生儿黄疸患儿血清胆红素水平的影响  

Effect of bacillus subtilis granules combined with Yinzhihuang granules on serum bilirubin levelsin children with moderate and mild neonatal jaundice

作　　者：吴小燕 陈薇薇 张小红 WU Xiaoyan;CHEN Weiwei;ZHANG Xiaohong(Department of Pediatric,the First People's Hospital of Jiujiang,Jiujiang,Jiangxi,332000,China;Department of Obstetrics and Gynecology,the First People's Hospital of Jiujiang,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市第一人民医院儿科,江西九江332000 [2]九江市第一人民医院妇产科,江西九江332000

出　　处：《当代医学》2023年第5期77-79,共3页Contemporary Medicine

摘　　要：目的分析枯草杆菌二联活菌颗粒联合茵栀黄颗粒对中轻度新生儿黄疸患儿血清胆红素水平的影响。方法选取2020年1—12月本院收治的中100例轻度新生儿黄疸患儿作为研究对象,按照随机数字法分为参照组与联合组,各50例。参照组予以茵栀黄颗粒治疗,联合组予以枯草杆菌二联活菌颗粒联合茵栀黄颗粒治疗,比较两组治疗前后经皮胆红素和血清总胆红素水平、治疗起效时间、黄疸消退时间、临床疗效及不良反应发生情况。结果治疗前,两组经皮胆红素和血清总胆红素水平比较差异无统计学意义;治疗后,两组经皮胆红素、血清总胆红素水平均低于治前,且联合组低于参照组,差异有统计学意义(P<0.05)。联合组治疗起效时间和黄疸消退时间均短于参照组,差异有统计学意义(P<0.05)。联合组治疗总有效率为96.00%,高于参照组的80.00%,差异有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义。结论枯草杆菌二联活菌颗粒联合茵栀黄颗粒治疗中轻度新生儿黄疸效果确切,有利于促进患儿血清胆红素水平恢复,加速病情康复,且安全性较高。Objective To analyze the effect of bacillus subtilis granules combined with Yinzhihuang granules on serum bilirubin level in children with moderate and mild neonatal jaundice.Methods 100 children with moderate and mild neonatal jaundice admitted to our hospital from January to December 2020 were selected as the research subjects,and they were divided into control group and combined group according to random number method,with 50 cases in each group.The control group was treated with Yinzhihuang granules,and the combined group was treated with bacillus subtilis granulescombined with Yinzhihuang granules,the levels of transcutaneous bilirubin and serum total bilirubin before and after treatment,the onset time of treatment,jaundice regression time,clinical efficacy and adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference inthe levels of transcutaneous bilirubin and serum total bilirubin between the two groups;after treat-ment,the levels of transcutaneous bilirubin and serum total bilirubin of the two groups were lower than before treatment,and the combined group were lower than the control group,and the differences were statistically significant(P<0.05).The onset time of treatment and jaundice regression time in the combination group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The totaleffec-tive rate of 96.00%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).There was no signif-icant difference in the incidence of adverse reactions between the two groups.Conclusion Bacillus subtilis granules combined with Yinzhihuang granules in the treatment of mild neonatal jaundice effect is exact,can promote the recovery of serum bilirubin levelin children,accelerate the recov-ery of the disease,and has high safety.

关 键 词：枯草杆菌二联活菌颗粒 茵栀黄颗粒 新生儿黄疸 血清胆红素 

分 类 号：R722.17[医药卫生—儿科]