脊柱微创通道镜系统辅助椎间孔腰椎椎间融合术对腰椎退行性疾病患者疼痛及氧化应激反应的影响  

Effect of transforaminal lumbar interbody fusion assisted by minimally invasive spinal channel system on pain and oxidative stress in patients with lumbar degenerative diseases of the lumbar spine

作　　者：吴昊[1] 张兴庆 WU Hao;ZHANG Xingqing(Department of Orthopaedics,the First Affiliated Hospital of China Medical University,Anshan Hospital,Liaoning,Anshan,114012,China)

机构地区：[1]中国医科大学附属第一医院鞍山医院骨科,辽宁鞍山114000

出　　处：《当代医学》2023年第1期130-132,共3页Contemporary Medicine

摘　　要：目的探究脊柱微创通道镜系统辅助椎间孔腰椎椎间融合术(TLIF)对腰椎退行性疾病患者疼痛及氧化应激反应的影响。方法选取2018年1月至2021年1月本院收治的100例腰椎退行性疾病患者作为研究对象,采用随机数字表法分为观察组和对照组,每组50例。对照组行TLIF术治疗,观察组在脊柱微创通道镜系统辅助下行TLIF术治疗,比较两组手术情况及手术前后日本骨科学会(JOA)评分、视觉模拟评分法(VAS)评分、氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、超氧化物歧化酶(SOD)]。结果观察组术中失血量、术后引流量均少于对照组,术后下床时间短于对照组,差异有统计学意义(P<0.05)。术前,两组JOA及腿、腰VAS评分比较差异无统计学意义;术后2周,两组腿、腰VAS评分均低于术前,JOA评分均高于术前(P<0.05),但组间比较差异无统计学意义。术前,两组GSH-Px、SOD、MDA水平比较差异无统计学意义;术后3d,两组血清GSH-Px、SOD水平均低于术前,血清MDA水平均高于术前,但观察组血清GSH-Px、SOD水平均高于对照组,MDA水平低于对照组,差异有统计学意义(P<0.05)。结论脊柱微创通道镜系统辅助TLIF术在保证腰椎退行性疾病患者临床疗效的前提下,可减轻患者术中创伤,缓解患者疼痛感及氧化应激反应,促进患者术后恢复,值得临床推广应用。Objective To analysis the effects of transforaminal lumbar interbody fusion(TLIF)assisted by minimally invasive spinal channel system on pain and oxidative stress in patients with lumbar degenerative diseases of the lumbar spine.Methods A total of 100 patients with lumbar degenerative diseases admitted to our hospital from January 2018 to January 2021 were selected as research subjects,and they were divided into observation group and control group by random number table method,with 50 cases in each group.The control group was treated with TLIF,and the observation group was treated with TLIF assisted minimally invasive spinal channel system,the operation condition,and Japanese Orthopaedic Association(JOA)score,visual analogue scale(VAS)score,oxidative stress index(glutathione peroxidase[GSH-Px],malondialdehyde[MDA],superoxide dismutase[SOD])before and after operation were compared between the two groups.Results The intraoperative blood loss and postoperative drainage volume in the observation group were less than those in the control group,and the time of getting out of bed after operation was shorter than that of the control group,the difference was statistically significant(P<0.05).Before operation,there was no significant difference in JOA score and leg and low back VAS scores between the two groups;at 2 weeks after operation,the leg and low back VAS scores of two groups were lower than those before operation,and JOA scores were higher than those before operation(P<0.05),but there was no significant difference between the two groups.Before operation,there was no significant difference in GSH-Px,SOD and MDA levels between the two groups;3 d after operation,the serum GSH-Px and SOD levels of the two groups were lower than those before operation,and the serum MDA level was higher than that before operation,but the serum GSH-Px and SOD levels in the observation group were higher than those in the control group,and the MDA level was lower than that in the control group,the differences were statistically significant(

关 键 词：腰椎退行性疾病 脊柱微创通道镜系统 椎间孔腰椎椎间融合术 

分 类 号：R687.3[医药卫生—骨科学]