丙酸氟替卡松乳膏治疗寻常性银屑病的临床疗效  

Clinical efficacy of fluticasone propionate cream in the treatment of psoriasis vulgaris

作　　者：于庆 YU Qing(Department of Pharmacy,Dalian Dermatology Hospital,Dalian,Liaoning,116021,China)

机构地区：[1]大连市皮肤病医院药剂科,辽宁大连116021

出　　处：《当代医学》2023年第3期46-49,共4页Contemporary Medicine

摘　　要：目的探究丙酸氟替卡松乳膏治疗寻常性银屑病的临床疗效。方法选取2020年1月至2021年4月本院收治的172例寻常型银屑病患者作为研究对象,按照治疗方法不同分为两组,每组86例。对照组给予常规治疗,观察组在对照组基础上联合丙酸氟替卡松乳膏治疗,比较两组临床疗效、局部不良反应发生率、治疗前后皮损面积和严重程度指数(PASI)评分、治疗前后体表受累面积(BSA)评分、生命质量评分。结果观察组治疗总有效率(96.51%)高于对照组(87.21%),差异有统计学意义(P<0.05)。观察组局部不良反应发生率(1.16%)低于对照组(8.14%),差异有统计学意义(P<0.05)。两组PASI评分组间、时间、交互比较差异有统计学意义(P<0.05);两组治疗后各时间PASI评分均低于前一时间点,且观察组低于对照组,差异有统计学意义(P<0.05)。两组SBA评分组间、时间、交互比较差异有统计学意义(P<0.05);两组治疗后各时间SBA评分均低于前一时间点,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组生理状态、心理情绪、社会状态、自我效能评分比较差异无统计学意义;治疗后,观察组生理状态、心理情绪、社会状态、自我效能评分均高于对照组,差异有统计学意义(P<0.05)。结论在常规治疗基础上联合丙酸氟替卡松乳膏治疗寻常型银屑病临床疗效显著,可缩小患者皮损面积,改善生理状态,值得临床推广应用。Objective To explore the clinical efficacy of fluticasone propionate cream in the treatment of psoriasis vulgaris.Methods 172 patients with psoriasis vulgaris treated in our hospital from January 2020 to April 2021 were selected as the research subjects,and they were divided into two groups according to different treatment methods,with 86 cases in each group.The control group was given routine treatment,while the observation group was treated with fluticasone propionate cream on the basis of the control group,the clinical efficacy,the incidence of local adverse reactions,the score of skin lesion area and severity index(PASI),the score of body surface involvement area(BSA)and the score of quality of life before and after treatment were compared between the two groups.Results The total effective rate in the observation group(96.51%)was higher than that in the control group(87.21%),and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(1.16%)was lower than that in the control group(8.14%),and the difference was statistically significant(P<0.05).There were significant differences in PASI scores between groups,time and interaction between the two groups(P<0.05);the PASI scores of the two groups at each time point after treatment were lower than those at the previous time point,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).There were significant differences in SBA scores between groups,time and interaction between the two groups(P<0.05);the SBA scores of the two groups at each time point after treatment were lower than those at the previous time point,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference between the two groups in the scores of physical state,psychological mood,social state and self-efficacy;after treatment,the scores of physical state,psychologic

关 键 词：丙酸氟替卡松乳膏 寻常性银屑病 体表受累面积 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]