改良低分子肝素皮下注射方法在老年冠状动脉粥样硬化性心脏病患者经皮冠状动脉介入治疗术后中的应用  

Application of modified low molecular weight heparin subcutaneous injection in elderly patients with coronary atherosclerotic heart disease after percutaneous coronary intervention

作　　者：王宏 曹爱丽 邱婷婷 杨娟 WANG Hong;CAO Aii;QIU Tingting;YANG Juan(Central hospital of Minhang district,Shanghai,201100,China)

机构地区：[1]上海市闵行区中心医院,上海201100

出　　处：《当代医学》2023年第3期184-187,共4页Contemporary Medicine

摘　　要：目的探讨改良低分子肝素皮下注射方法在老年冠状动脉粥样硬化性心脏病(冠心病)患者经皮冠状动脉介入治疗术后中的应用。方法采取方便抽样法选取2019年1—12月于本院行PCI术后的84例老年冠心病患者作为研究对象,随机分为对照组与实验组,各42例。对照组行传统低分子肝素皮下注射,实验组行改良低分子肝素皮下注射,比较两组出血发生率、出血程度、皮下硬结发生率及数字评分疼痛量表(NRS)评分。结果实验组皮下出血发生率为7.31%,低于对照组的20.41%,差异有统计学意义(P<0.05);实验组皮下出血程度轻于对照组,差异有统计学意义(P<0.05);实验组皮下硬结发生率、NRS评分均低于对照组,差异有统计学意义(P<0.05)。结论应用改良法对老年冠心病PCI术后进行皮下注射低分子肝素,能显著降低患者注射出血、皮下硬结发生率,减轻疼痛强度,值得临床推广应用。Objective To investigate the application of modified low molecular weight heparin subcutaneous injection in elderly patients with coronary atherosclerotic heart disease after percutaneous coronary intervention(PCI).Methods 84 elderly patients with coronary atherosclerotic heart disease(CHD)who underwent PCI in our hospital from January to December 2019 were selected as the research subjects,and they were randomly divided into control group and experimental group,with 42 cases in each group.The control group received subcutaneous injection of traditional low molecular weight heparin,and the experimental group received modified low molecular weight heparin subcutaneous injection,the incidence of bleeding,the degree of bleeding,the incidence of subcutaneous sclerosis and the score of numerical rating scale(NRS)were compared between the two groups.Results The incidence of subcutaneous hemorrhage in the experimental group was 7.31%,which was significantly lower than 20.41%in the control group,and the difference was statistically significant(P<0.05);the degree of subcutaneous hemorrhage in the experimental group was lighter than that in the control group,and the difference was statistically significant(P<0.05);the incidence of subcutaneous sclerosis and the NRS score in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Subcutaneous injection of low molecular weight heparin after PCI in elderly patients with coronary heart disease can significantly reduce the incidence of injection hemorrhage and subcutaneous sclerosis,and reduce the intensity of pain,which is worthy of clinical promotion and application.

关 键 词：老年人 冠状动脉粥样硬化性心脏病 经皮冠状动脉介入术 低分子肝素 

分 类 号：R541.4[医药卫生—心血管疾病]