锌剂辅助治疗小儿轮状病毒性肠炎的近期疗效及对不良反应和短期复发的影响  

Short-term efficacy of zinc adjuvant therapy on rotavirus enteritis in children and its effect on adverse reactions and short-term recurrence

作　　者：孙文慧[1] 薛娇 叶冰[1] SUN Wenhui;XUE Jiao;YE Bing(Department of Emergency,Ji'nan Children's Hospital,Ji'nan,Shandong,250022,China)

机构地区：[1]济南市儿童医院急诊科,山东济南250022

出　　处：《当代医学》2023年第4期23-25,共3页Contemporary Medicine

摘　　要：目的探讨锌剂辅助治疗小儿轮状病毒性肠炎的近期疗效及对短期复发的影响。方法选取2019年5月至2021年5月济南市儿童医院收治的110例轮状病毒性肠炎患儿作为研究对象,基于随机抽签法分为对照组与实验组,每组55例。对照组给予常规治疗,实验组在对照组基础上联合锌剂辅助治疗,比较两组症状持续时间、近期疗效、不良反应发生率及短期复发情况。结果实验组发热、呕吐、轻中度脱水、腹泻持续时间均短于对照组,差异有统计学意义(P<0.05)。实验组治疗总有效率为94.55%,高于对照组的80.00%,差异有统计学意义(P<0.05)。实验组不良反应发生率为9.09%,低于对照组的25.45%,差异有统计学意义(P<0.05)。实验组30、60、90d复发率均低于对照组,差异有统计学意义(P<0.05)。结论锌剂辅助治疗轮状病毒性肠炎效果显著,可缩短患儿临床症状持续时间,治疗安全性高,且还可降低短期复发率,值得临床推广应用。Objective To investigate the short-term efficacy of zinc adjuvant therapy on rotavirus enteritis in children and its effect on short-term recurrence.Methods A total of 110 children with rotavirus enteritis admitted to Ji'nan Children's Hospital from May 2019 to May 2021 were select-ed as research subjects,and they were divided into control group and experimental group according to random lottery method,with 55 cases in each group.The control group was given conventional treatment,and the experimental group was given zinc adjuvant treatment on the basis of the con-trol group,the duration of symptoms,short-term efficacy,incidence of adverse reactions and short-term recurrence were compared between the two groups.Results The duration of fever,vomiting,mild and moderate dehydration and diarrhea in the experimental group was shorter than that in the control group,the differences were statistically significant(P<0.05).The total effective rate in the experimental group was 94.55%,which was high-er than 80.00%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimen-tal group was 9.09%,which was lower than 25.45%in the control group,and the difference was statistically significant(P<0.05).The recurrence rate at 30,60 and 90 d in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Zinc adjuvant treatment of children with rotavirus enteritis has significant effect,can shorten the duration of clinical symptoms,high safety,and can reduce the short-term recurrence rate,worthy of clinical promotion and application.

关 键 词：轮状病毒性肠炎 锌剂辅助治疗 常规治疗 短期复发 临床症状 

分 类 号：R725.1[医药卫生—儿科]