基于因子分析和聚类分析的慢性弥漫性休止期脱发患者六经辨证分型研究  

Research on Six-channel Pattern Differentiation in Patients with Chronic Diffuse Telogen Hair Loss based on Factor Analysis and Cluster Analysis

作　　者：钟施怡 庄明月 田子园 刘青武 杨顶权[2] ZHONG Shiyi;ZHUANG Mingyue;TIAN Ziyuan;LIU Qingwu;YANG Dingquan(Graduate School of Beijing University of Chinese Medicine,Beijing,100029;China-Japan Friendship Hospital)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中日友好医院

出　　处：《中医杂志》2023年第16期1670-1677,共8页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81973691)。

摘　　要：目的探索慢性弥漫性休止期脱发(CDTHL)的六经辨证分型规律。方法纳入2018年8月至2022年8月于中日友好医院皮肤病门诊诊断为CDTHL患者。制定中医症状评分量表,收集一般资料和中医四诊信息。统计患者中医四诊信息分布情况,运用因子分析法对四诊信息进行降维,将特征根>1的初始公因子得分作为变量进行聚类分析,总结CDTHL的常见六经辨证分型。结果研究共纳入182例CDTHL患者,出现频数(频率)排名前十位的四诊信息中依次为头皮出油159例(87.36%),焦虑135例(74.18%),头皮瘙痒132例(72.53%),多梦128例(70.33%),头屑124例(68.13%),心烦118例(64.84%),疲劳感117例(64.29%),易怒116例(63.74%),紧张102例(56.04%),疲倦乏力98例(53.85%)。患者的中医四诊信息可提取14个特征根>1的公因子,14个公因子可被聚为3类,结合《伤寒杂病论》、既往共识及专家经验可将聚类结果归纳为太阴病证(脾虚胃热,湿热内蕴证),少阴病证(肾阳不足,气化失权证),厥阴病证(肝肾阴虚,寒热错杂证)。结论CDTHL为本虚标实之证,证型分布为太阴病证、少阴病证、厥阴病证。Objective To explore the law of six-channel pattern differentiation in chronic diffuse telogen hair loss(CDTHL).Methods Patients diagnosed with CDTHL at the dermatology department of China-Japan Friendship Hospital from 2018 August to 2022 August were included.Traditional Chinese medicine(TCM)symptom scale was developed to collect general information and the four examinations information.The distribution of the four examinations information of TCM was counted,and the factor analysis was conducted to reduce the dimensionality.The initial common factor score of the characteristic root 1 was used as a variable for cluster analysis,and the common sixchannel syndrome of CDTHL was summarized.Results A total of 182 CDTHL patients were included,and the top ten frequent four examinations information were oily scalp(159,87.36%),anxiety(135,74.18%),scalp pruritus(132,72.53%),dreaminess(128,70.33%),dandruff(124,68.13%),upset(118,64.84%).tiredness(117,64.29%),irritability(116,63.74%),nervousness(102,56.04%),and fatigue(98,53.85%).Fourteen common factors with characteristic roots 1 were obtained from the patient's four examinations information of TCM,and were clustered into 3 categories based on Treatise on Cold Damage and Miscellaneous Diseases(《伤寒杂病论》),previous consensus and expert experience,which were taiyin(太阴)disease pattern(spleen deficiency and stomach heat,damp-heat internal accumulation pattern),shaoyin(少阴)disease pattern(kidney yang insufficiency,qi transformation failure pattern),and jueyin(厥阴)disease pattern(liver-kidney yin deficiency,cod-heat complex pattern).Conclusion CDTHL is of root deficiency and branch excess,and the patterns were taiyin disease pattern,shaoyin disease pattern,and jueyin disease pattern.

关 键 词：慢性弥漫性休止期脱发 六经辨证 因子分析 聚类分析 

分 类 号：R275.9[医药卫生—中西医结合]