慢性乙型肝炎患者运气禀赋与显著肝纤维化的关联性研究  

Relevance research on Yunqi endowment and significant liver fibrosis in patients with chronic hepatitis B

作　　者：谢玉宝[1] 萧焕明[1] 施梅姐[1] 蔡高术[1] 张朝臻[1] 黎胜[1] 池晓玲[1] XIE Yubao;XIAO Huanming;SHI Meijie;CAI Gaoshu;ZHANG Chaozhen;LI Sheng;CHI Xiaoling(Hepatology Department,Guangdong Provincal Hospital of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广东省中医院肝病科,广州510120

出　　处：《中华中医药杂志》2023年第8期3857-3863,共7页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家“十三五”重大传染病专项(No.2018ZX10725506-003);国家中医药管理局全国名老中医药专家池晓玲传承工作室建设项目(No.国中医药办人教函[2022]75号);广东省中医院樊正伦学术经验传承工作室项目(No.广中医文[2014]089号);广东省中医院优势病种建设项目(No.中医二院[2020]37号)。

摘　　要：目的:探索慢性乙型肝炎患者运气禀赋与出现显著肝纤维化的关联性。方法:选取广东省中医院肝病科2009年1月至2013年1月住院行肝脏组织病理检查的慢性乙型肝炎患者共740例,记录患者的基本信息,采用多因素Logistic回归模型分析患者受孕及出生时的运气禀赋与发生显著肝纤维化的关联。结果:出生时段为少阴君火司天的慢性乙型肝炎患者发生显著肝纤维化的风险显著增加[OR=2.00,95%CI(1.08,3.69)]。主气少阳相火时段受孕[OR=0.53,95%CI(0.29,0.94)]、客气阳明燥金时段受孕[OR=0.52,95%CI(0.28,0.95)]、己年出生[OR=0.43,95%CI(0.19,0.99)]、辛年出生[OR=0.45,95%CI(0.20,0.99)]的慢性乙型肝炎患者均降低出现显著肝纤维化的风险(P<0.05)。结论:先天运气禀赋与慢性乙型肝炎患者出现显著肝纤维化存在着一定的关联性,受孕时段及出生时段运气因素均有影响。Objective:To explore the relationship between Yunqi endowment and significant liver fibrosis in chronic hepatitis B patients.Methods:A total of 740 patients with chronic hepatitis B who underwent liver histopathological examination in the Hepatology Department of Guangdong Provincial Hospital of Chinese Medicine from January 2009 to January 2013 were selected,the basic information of the patients was recorded.A multivariate Logistic regression model was used to analyze the association between the Yunqi endowment and the occurrence of significant liver fibrosis.Results:Chronic hepatitis B patients born during the period of Shaoyin Junhuo sitian had a significantly higher risk of developing significant liver fibrosis[OR=2.00,95%CI(1.08,3.69)].Conception during the period of main Qi Shaoyang Xianghuo[OR=0.53,95%CI(0.29,0.94)],pregnancy during the period of polite Yangming Zaojin[OR=0.52,95%CI(0.28,0.95)],birth in Ji year[OR=0.43,95%CI(0.19,0.99)],and chronic hepatitis B patients born in Xin year[OR=0.45,95%CI(0.20,0.99)]had a reduced risk of significant liver fibrosis(P<0.05).Conclusion:There is a certain correlation between the innate Yunqi endowment and the significant liver fibrosis in patients with chronic hepatitis B,and both the time of conception and the time of birth are affected by Yunqi factors.

关 键 词：五运六气 慢性乙型肝炎 肝纤维化 运气禀赋 

分 类 号：R259[医药卫生—中西医结合]