妊娠糖尿病孕妇娩出低体质量儿影响因素分析  

Analysis of influencing factors of low birth weight infants delivered by pregnant women with gestational diabetes mellitus

作　　者：张攀 饶佳为 张金凤 韩凤琼 钟妮 张澳 陈嘉燊 潘海燕 ZHANG Pan;RAO Jiawei;ZHANG Jinfeng;HAN Fengqiong;ZHONG Ni;ZHANG Ao;CHENG Jiashen;PAN Haiyan(Department of Epidemiology and Health Statistics of Guangdong Medical University,Dongguan,Guangdong 523808,China;Shunde Women’s and Children’s Hospital of Guangdong Medical University,Foshan,Guangdong 528300,China)

机构地区：[1]广东医科大学流行病与卫生统计学教研室,广东东莞523808 [2]广东医科大学顺德妇女儿童医院,广东佛山528300

出　　处：《中国优生与遗传杂志》2023年第8期1545-1550,共6页Chinese Journal of Birth Health & Heredity

基　　金：广东省自然科学基金面上项目(2019A1515010875);2020年东莞市科技特派员项目(20201800500082);广东省普通高校重点平台重点领域专项项目(2020ZDZX3007);广东省医学科研基金项目(B2019087);广东医科大学大学生创新创业训练计划项目(GDMU2018134);广东医科大学-南方医科大学两校结对科研团队项目(4SG23035G)。

摘　　要：目的 探讨妊娠糖尿病(GDM)孕妇娩出低体质量儿相关危险因素。方法 选取佛山市某妇女儿童医院于2019年6月至2020年6月1732例GDM孕妇作为研究对象,其中171例为低体质量儿组,1561例为非低体质量儿组。采用单因素分析和多因素Logistic回归分析,分析GDM孕妇娩出低体质量儿相关危险因素。结果 两组间的宫高、羊水量、胎膜早破率、胎盘早剥率、妊娠合并高血压性疾病率、双胎妊娠率、胚胎移植率等指标均存在差异,且差异具有统计学意义(P<0.05);将单因素分析差异有统计学意义的指标纳入多因素Logistic回归分析,宫高低、羊水过少、双胎妊娠、妊娠合并高血压疾病、高OGTT 1 h值、高WBC值、低ALB值、高GGT值、胎膜早破均为GDM娩出低体质量儿的独立危险因素。结论 对于有上述危险因素的GDM孕产妇,应当加强监测与管理,控制围生期母婴感染及炎症的发生,密切监测胎儿的生长发育状态,通过有效干预降低低体质量儿的发生率,减少母婴不良妊娠结局。Objective To explore the risk factors associated with the delivery of low birth weight babies in pregnant women with gestational diabetes mellitus.Methods A total of 1732 pregnant women with GDM in Foshan Women and Chil-dren’s Hospital from June 2019 to June 2020 were selected for the study,of which 171 were in the low birth weight group and 1561 were in the non-low birth weight group.Single-factor analysis and multi-factor Logistic regression analysis were used to analyze the risk factors associated with the delivery of low-birth-weight infants in pregnant women with GDM.Results There were significant differences in uterine height,amniotic fluid volume,premature rupture of membranes,placental abruption rate,pregnancy complicated with hypertension,twin pregnancy rate and embryo transfer rate between the two groups(P<0.05).Logistic regression analysis showed that uterine height,oligohydramnios,twin pregnancy,pregnancy with hypertension,high OGTT 1 h value,high WBC value,low ALB value,high GGT value and premature rupture of membranes were independent risk factors for low birth weight infants with GDM.Conclusion For pregnant women with GDM who have the above risk factors,monitoring and management should be strengthened to control perinatal infections and inflammation in mother and baby,closely monitor fetal growth and development,reduce the incidence of low birth weight babies through effective inter-ventions,and reduce adverse pregnancy outcomes for mother and baby.

关 键 词：妊娠糖尿病 低体质量儿 影响因素 

分 类 号：R714.256[医药卫生—妇产科学]