心脏移植免疫抑制药物服药依从性与结局的研究  

Correlations of outcome and adherence to immunosuppressants in heart transplant recipients

作　　者：张娟[1] 沈晓玲[1] 陈芬[1] 李雪燕 赵芹玉 Zhang Juan;Shen Xiaoling;Chen Fen;Li Xueyan;Zhao Qinyu(Department of Thoracic Surgery,East Hospital,People's Hospital of Wuhan University,Wu Han 430060,Hu Bei,China)

机构地区：[1]武汉大学人民医院东院胸外科,湖北武汉430223

出　　处：《实用器官移植电子杂志》2023年第4期344-348,共5页Practical Journal of Organ Transplantation(Electronic Version)

摘　　要：目的探讨心脏移植受者免疫抑制药物服药依从性与服药信念和患者结局间的关系。方法采用便利抽样法,选取118例心脏移植受者,使用一般情况调查表、免疫抑制药物依从性Basel评估量表(Basel Assessment of Adherence with Immunosuppressive medication Scale,BAASIS)、服药信念量表(Beliefs about Medication Questionnaire,BMQ)进行调查。结果58.62%心脏移植受者术后服药依从性差,服药信念各维度得分:药物有害(11.12±2.83)分、药物过度使用(10.07±2.62)分、服药必要性(18.19±2.43)分、服药顾虑(16.21±3.89)分,服药必要性与顾虑差值得分为(1.98±5.03)分。服药依从性与药物过度使用、服药顾虑、服药必要性与顾虑差值的得分比较,差异有统计学意义(P<0.05)。服药依从性与排斥反应、非计划性入院成正相关,与是否发生术后并发症成负相关,差异有统计学意义(P<0.05)。结论心脏移植受者服药依从性较差,服药依从性与服药信念及患者结局密切相关,应提高患者的服药信念,促进其服药依从性,从而改善患者结局。Objective To explore the correlations of belief,outcome and adherence to immunosuppressants in heart transplant recipients.Methods A survey was conducted on 116 heart transplant recipients.The instruments included a self-designed general information questionnaire,the Basel Assessment of Adherence with Immunosuppressive Medication Scale(BAASIS)and Beliefs about Medication Questionnaire(BMQ).Results 58.62%heart transplant recipients were non-adherent.The recipients score was(11.12±2.83)on harm of medication,(10.07±2.62)on overuse of medication,(18.19±2.43)on necessity of prescribed medication and(16.21±3.89)on concerns about potential adverse consequences.The mean necessity-concerns differential was(1.98±5.03).The scores of overuse,concerns and necessity-concerns differential between the adherent and non-adherent recipients had significant differences(P<0.05).Medication adherence was positively correlated with rejection and unplanned admission,and negatively correlated with postoperative complications(P<0.05).Conclusion Medication adherence is closely related to medication belief and patient outcomes.It is necessary to improve the medication belief of patients and promote their medication adherence,so as to improve patient outcomes.

关 键 词：心脏移植 受者 服药依从性 服药信念 免疫抑制药物 

分 类 号：R473.6[医药卫生—护理学]