五环三萜类化合物的抗肝炎病毒活性研究进展  

Research Progress of the Anti-hepatitis Virus Activity of Pentacyclic Triterpenoids

作　　者：刘国涛 高昊宇 孔明月 王艳丽 王伟 王强[4] LIU Guotao;GAO Haoyu;KONG Mingyue;WANG Yanli;WANG Wei;WANG Qiang(Henan Institute of Reproductive Health Science and Technology,Zhengzhou 450000,China;Department of Thoracic Surgery,the First Hospital of China Medical University,Shenyang 110000,China;Henan Natural Products Biotechnology Co.Ltd.,Zhengzhou 450000,China;High&New Technology Research Center,Henan Academy of Sciences,Zhengzhou 450000,China)

机构地区：[1]河南省生殖健康科学技术研究院,郑州450000 [2]中国医科大学附属第一医院胸外科,沈阳110000 [3]河南省纳普生物科技有限公司,郑州450000 [4]河南省科学院高新技术研究中心,郑州450000

出　　处：《河南科学》2023年第8期1102-1111,共10页Henan Science

基　　金：河南省科技攻关项目(232102310401,222102310400);河南省自然科学基金项目(232300420072)。

摘　　要：五环三萜是一类次生植物代谢产物,由异戊二烯(2-甲基丁二烯)(C5H8)单元构成,其具有抗病毒、抗肿瘤、抗炎等多种药理活性.以五环三萜类化合物甘草酸、甘草次酸、雷公藤红素、白桦脂酸、齐墩果酸、熊果酸、柴胡皂苷C为例,总结五环三萜类化合物及其衍生物抗甲型肝炎病毒、乙型肝炎病毒和丙型肝炎病毒的活性及构效关系和作用机制.相关研究表明该类化合物主要通过抑制病毒复制和进入宿主细胞以及调节机体免疫来发挥作用,这一结果为结构新颖、作用机制独特、毒副作用低的新型抗病毒抑制剂的设计提供了重要依据.Pentacyclic triterpenoids(PTs)are a class of natural products derived from plants and fungi.They are composed of three terpene units and have various biological activities,such as antiviral,anti-tumor,and anti-inflammatory effects.This paper reviews the antiviral activity,structure-activity relationship and mechanism of action of pentacyclic triterpenoids and their derivatives against hepatitis A virus(HAV),by hepatitis B virus(HBV)and hepatitis C virus(HCV),by using glycyrrhizic acid,glycyrrhetinic acid,Celastrol,betulinic acid,oleanolic acid,ursolic acid and Saikosaponin C as examples.These compounds mainly exert their effects by inhibiting viral replication and entry into host cells and modulating immune responses.This review provides an important basis for the design of novel antiviral inhibitors with unique structures,mechanisms and low toxicity.

关 键 词：天然产物 五环三萜 肝炎病毒 构效关系 

分 类 号：R932[医药卫生—生药学]