基于数据挖掘的中药内服治疗腰椎间盘突出症术后残留症状用药规律研究  

A data mining-based analysis of dlinical medication rules of oral Chinese herbal medicine prescriptions for treatment of residual symptoms after surgery for lumbar disc herniation

作　　者：王一迪 范利娟 石洋 白超楠 崔宏勋 WANG Yidi;FAN Lijuan;SHI Yang;BAI Chaonan;CUI Hongxun(Postgraduate College of Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;Luoyang Orthopedic-Traumatological Hospital,Zhengzhou 450016,Henan,China)

机构地区：[1]河南中医药大学研究生院,河南郑州450046 [2]河南省洛阳正骨医院/河南省骨科医院,河南郑州450016

出　　处：《中医正骨》2023年第8期37-42,共6页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：全国中医药创新骨干人才项目(国中医药人教函[2019]128号);河南省中医药拔尖人才项目(豫中医科教[2018]25号)。

摘　　要：目的:探讨中药内服治疗腰椎间盘突出症术后残留症状的用药规律。方法:利用计算机检索中国知网、万方数据库、维普网、PubMed、Web of Science中有关中药内服治疗腰椎间盘突出症术后残留症状的文献,检索时限均为建库至2023年1月31日。提取入选文献中的内服方剂,统计方剂的主治证型、药物组成,以及药物的功效、性、味、归经。采用Microsoft Excel 2021软件统计药物的主治证型、出现频次,以及药物的功效、性、味、归经分布情况。采用SPSS Modeler 18.0软件对筛选出的高频药物进行关联规则分析,采用SPSS Statistics 21.0软件对筛选出的高频药物进行聚类分析。结果:纳入研究的文献共117篇,包含123首内服方剂。方剂的主治证型主要有4个,其中气滞血瘀证(42次)、肾虚血瘀证(35次)、肝肾亏虚证(23次)的出现频次较高。123首内服方剂涉及183味中药,累计出现1363次,其中出现频次≥20的药物共20味,排在前3位的依次为当归(82次)、甘草(70次)、牛膝(66次)。药物功效统计结果显示,补虚药(453次)、活血化瘀药(378次)、祛风湿药(147次)的出现频次较高。药性统计结果显示,温性药(664次)、平性药(397次)的出现频次较高。药味统计结果显示,甘味药(746次)、苦味药(624次)、辛味药(592次)的出现频次较高。药物归经统计结果显示,归肝经(900次)、脾经(599次)、肾经(438次)的药物出现频次较高。将出现频次≥20的中药作为高频药物,通过关联规则分析得到11条关联规则,其中前3位依次为川芎→当归、黄芪→当归、红花→当归;涉及7个核心药物,主要为补虚药(黄芪、当归、甘草)和活血化瘀药(红花、川芎、赤芍、桃仁);通过聚类分析,得到4类药物组合。结论:中药内服治疗腰椎间盘突出症术后残留症状的用药规律为,以补虚药为主,辅以活血化瘀药;多用药性温、平,药味甘、苦、辛,归肝经、脾经、�Objective:To excavale the clinical medication rules of oral Chinese herbal medicine(CHM)prescriptions in treatment of re sidual symptoms after surgery for lumbar disc herniation(LDH).Methods:All artidles aboul oral CHM prescriptions for trealment of residu-al symptoms emerged after surgery for LDH included from database establishing to January 31,2023 were retrieved from the China National Knowledge Intemet,W anfang Database,Vip Database,PubMed and Web of Science through computer.The obtained articles were screened according to the predefined inclusion and exclusion criteria,and the oral CHM prescriptions were extracted from the included artidles,fol-lowed by statistics on the indications,ingredients contained in the CHM prescriptions as well as the efficacy,medicinal property,medicinal flavor and merdian tropism of each Chinese herbs(CHs)in prescriptions.The normalized and standardized CHs in the extracted prescrip-tions were input into the Microsoft Office Excel 2021 software for building a database,based on which their indications,occurrence frequen-cy,ffcacy,medicinal property,medicinal flavor and meridian tropism were staistically analyzed.The high-frequency CHs were then subjec ted to association rule analysis by using SPSS Modeler 18.0 software and cluster analysis by using SPSS Statistics 21.0 software.Results:One hundred and seventeen articles were included in the final analysis,involving 123 oral CHM prescriptions,and they mainly acted on 4 indications,anong which Qi-stagnation and blood-stasis syndrome(42 times),kidney-deficiency and blood-stagnation syndrome(35 times)and liver-kidney deficiency syndrome(23 times)occurred more frequently.One hundred and eighty-three CHs(appeared 1363 times)were involved in the 123 oral CHM prescriptions,among which 20 ones displayed a occurrence frequency of≥20,and the top 3 ones with high occurrence frequency ineluded Angelicae Sinensis Radix(TCD)(82 times),Glyeyrthizae Radix et Rhizoma(TCD)(70 times)and Achyranthes Bidentalae Radix(TCD)(66 times).The results of sta

关 键 词：椎间盘移位 腰椎 手术后并发症 中药 方剂分析 计算机辅助 数据挖掘 

分 类 号：R274.9[医药卫生—中西医结合]