基于中医传承辅助平台探讨国家专利中药复方治疗骨髓炎的组方规律  

A data mining-based analysis of clinical medication rules of national patent Chinese herbal compound prescrip-tions against osteomyelitis based on traditional Chinese medicine inberitance support system

作　　者：吉富涛 闫露露 冯新越 黄鸿文 谢元洋 徐天利 陈葛 尹本敬[2] 顾海潮[2] JI Futao;YAN Lulu;FENG Xinyue;HUANG Hongwen;XIE Yuanyang;XU Tianli;CHEN Ge;YIN Benjing;GU Haichao(The First Clinical Medical College of Yunnan University of Chinese Medicine,Kunming 650500,Yunnan,China;Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650021,Yunnan,China)

机构地区：[1]云南中医药大学第一临床医学院,云南昆明650500 [2]云南省中医医院,云南昆明650021

出　　处：《中医正骨》2023年第8期51-56,60,共7页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：2022年云南省“兴滇英才支持计划”项目(云卫人发[2022]8号)。

摘　　要：目的:探讨国家专利中药复方治疗骨髓炎的组方规律。方法:通过计算机检索国家知识产权局中国专利公布公告网(http://epub.cnipa.gov.cn/)中治疗骨髓炎的中药复方,按照纳排标准筛选中药复方,将筛选出的中药复方的组方药物及其剂量分别录入Microsoft Office Excel 2010软件和中医传承辅助平台(V2.5),建立数据库。采用Microsoft Office Excel 2010软件统计每味药物的出现频次及药物的性、味、归经分布情况,通过中医传承辅助平台(V2.5)分析中药复方的组方规律,并聚类生成新方。结果:共收集到106首中药复方,涉及511味中药,其中因穿山甲为国家一级保护动物,故未对此药做统计。510味中药出现频次≥3的有150味,其中排名前20位的中药分别为金银花、当归、黄芪、甘草、蒲公英、没药、骨碎补、丹参、乳香、红花、紫花地丁、熟地黄、川牛膝、黄柏、黄连、党参、茯苓、川芎、牡丹皮、三七。106首中药复方的组方药物中,药性以寒性出现频次最多,其次为温性、平性;药味以苦味出现频次最多,其次为甘味、辛味;归经以肝经出现频次最多,其次为肾、脾、肺经;出现频次≥10的药物组合有10个,排在前3位的为金银花-黄芪、金银花-蒲公英、黄芪-当归;核心药物组合10个,分别为金银花-黄芪-黄连、射干-穿心莲-北沙参、全蝎-肉桂-鱼鳔、茯苓-天葵子-金樱子、伸筋草-鸡血藤-土牛膝、杜仲-续断-骨碎补、板蓝根-大黄-杏仁、三七-乳香-没药、知母-黄柏-苏木、熟地黄-鸡血藤-石膏。经聚类分析得出新处方5首,分别为金银花-黄芪-黄连-杜仲-续断-骨碎补、射干-穿心莲-北沙参-板蓝根-大黄-杏仁、全蝎-肉桂-鱼鳔-三七-乳香-没药、茯苓-天葵子-金樱子-知母-黄柏-苏木、伸筋草-鸡血藤-土牛膝-熟地黄-石膏。结论:国家专利中药复方治疗骨髓炎,多用性偏寒,味偏苦,入肝、肾、脾、肺经的中药;Objective:To explore the clinical medication rules of national patent Chinese herbal compound(CHC)prescriptions in treatment of ostcomyeltis.Methods:AllI CHC prescriptions for trealment of ostcomyelitis were relrieved from the website(htp://epub.cni-pa.gov.cn/)of China Patent Announcement of China National Inellectual Property Administration through computer.The obtained paltents wene screened,and the CHC presciptions involved in the patents were extracted according to the predefined indusion and exclusion cnite ria.The Chinese herbs and their corresponding dosages in the screened CHC prescriptions were standardized and input into the Microsoft Office Excel 2010 software and the Traditional Chinese Medicine Inheritance Support System(TCMISS)software(V2.5)respectively to build the database.The statis tics on occurrence frequency,properly,flavour,meridian tropism of Chinese berbs in CHC prescriptions were conduc-ted by using Microsoft Ofice Excel 2010 software,and their elinical medication nules were analyzed by using TCMISS software(V2.5),fur-themnore,the new presciptions were predicted by cluster analysis.Results:One hundred and six CHC prescriptions were included in the final analysis,involving 511 Chinese berbs,among which Manis Squama was exeluded from the statistics due to its original material came from the first-class national protected animal Manis pentadactyla Linnacus.Among the 510 Chinese herbs,150 ones displayed a occurrence frequency of≥3,and the top 20 ones with high occurrence frequency included Lonicerae Japonicae Flos,Angelica sinensis,Astragalus pro-pinquus,Glycyrhizae Radix et Rhizoma(TCD),Tanaxaci Herba,Myrrha,Drynariae Rhizoma,Salviae Miliorhizae Radix et Rhizoma(TCD),Olibanum(TCD),Carthami Flos(TCD),Violae Herba,Rehmanniae Radix Praeparata,Cyathula fficinalis,Pllodendri Chinensis Cortex,Coptidis Rhizoma,Codonopsis Radix,Poria(TCD),Chuanxiong Rhizoma,Moutan Cortex and Notoginseng Radix et Rhizoma(TCD).The results of statistics on medicinal property,flavor and meridian tropism showed that,amo

关 键 词：骨髓炎 复方(中药) 专利 数据挖掘 方剂构成 组方原则 聚类分析 

分 类 号：R274.9[医药卫生—中西医结合]