针刺在COVID-19治疗中的多效能特点与优势  

Multi-effective characteristics and advantages of acupuncture in COVID-19 treatment

作　　者：王利芬 胡细佑 耿连岐 李柠岑 陈勇 张靖宇 袁馨如 黄礼红 巴东升 廉金玉 吕笑颜 陈泽林[1,2,4] 章越 陈波 Lifen Wang;Xiyou Hu;Lianqi Geng;Ningcen Li;Yong Chen;Jingyu Zhang;Xinru Yuan;Lihong Huang;Dongsheng Ba;Jinyu Lian;Xiaoyan Lyu;Zelin Chen;Yue Zhang;Bo Chen(Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin,China;Fourth Teaching Hospital of Tianjin University of TCM Binhai New Area Hospital of TCM Tianjin,Tianjin,China;School of Acupuncture&Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin,China;National Clinical Research Center of Traditional Chinese Medicine and Acupuncture,Tianjin,China;Department of Neurosurgery,University of Pennsylvania,Philadelphia,the United States of America)

机构地区：[1]天津中医药大学实验针灸学研究中心 [2]天津中医药大学 [3]天津中医药大学第四附属医院 [4]国家中医针灸临床研究中心 [5]宾夕法尼亚大学

出　　处：《Acupuncture and Herbal Medicine》2023年第2期83-95,共13页针灸和草药（英文）

基　　金：supported by the National Natural Science Foundation of China(NSFC)(Nos.82004467,82030125 and 81573882);the National Key R&D Program of China(No.2019YFC1712200-2019YFC1712204).

摘　　要：COVID-19是威胁人类生命健康的重大疾病,其发病机制复杂且仍未完全阐明,临床多以支持治疗为主,缺乏特异性治疗方法。针刺治疗可抑制免疫炎性反应、神经炎症反应、氧化应激水平和下丘脑-垂体-肾上腺(HPA)轴活性,改善肺功能,缓解偏头痛、疲劳、焦虑和抑郁。然而,针刺疗法是否适合COVID-19患者相关症状的治疗仍有待研究。本文系统检索多个数据库,纳入相关研究性文献进行分析,归纳总结针刺治疗COVID-19相关症状、合并症的循证依据以及针刺治疗的机制,并对穴位和症状进行了复杂网络分析,以阐明针刺治疗COVID-19各系统相关症状的选穴规律。分析发现针刺主要通过抑制免疫炎性反应、调节肠道菌群、线粒体功能、氧化应激水平、心肌细胞凋亡、神经递质释放和HPA轴活性,改善COVID-19呼吸系统、消化系统、神经系统和精神心理障碍等相关症状,减轻心血管系统等基础疾病。针刺可以改善COVID-19的多种临床症状及合发症,但其作用机制复杂,仍需开展深入研究。Coronavirus disease 2019(COVID-19)is a major disease that threatens human life and health.Its pathogenesis is complex and still not fully clarified.The clinical treatment is mainly supportive and lacks specific treatment methods.Acupuncture treatment can inhibit immune inflammatory reactions,neuroinflammatory reactions,oxidative stress levels,and hypothalamus-pituitary-adrenal(HPA)axis activity,improve lung function,and relieve migraine,fatigue,anxiety,and depression.However,whether acupuncture treatment is suitable for treating these symptoms in patients with COVID-19 still needs to be investigated.For this review,the literature was systematically searched for multiple databases to summarize the mechanisms of acupuncture treatment for COVID-19-related symptoms and complications.A complex network analysis of acupoints and symptoms was also performed to clarify acupoint selection in the acupuncture treatment of symptoms related to COVID-19.The evidence indicates that acupuncture can improve the respiratory,digestive,nervous,and mental and psychological symptoms related to COVID-19 by inhibiting immune inflammatory reactions,regulating intestinal flora,mitochondrial function,oxidative stress level,cardiomyocyte apoptosis,neurotransmitter release,and HPA axis activity,and alleviating basic diseases such as diseases of the vascular system.Acupuncture can improve various clinical and concomitant symptoms of COVID-19;however,its mechanism of action is complex and requires further study.

关 键 词：COVID-19 炎症因子风暴 针刺 多效能 

分 类 号：R246.1[医药卫生—针灸推拿学]