西藏自治区藏族人群胆囊结石成分分析  

Chemical composition of gallstone in Tibetans from Tibet Autonomous Region

作　　者：陈彪 达瓦[1] 巴桑顿珠[1] 仁桑[1] 索郎多杰 CHEN Biao;Dawa;Basangdunzhu;Rensang;Suolangduojie(Department of General Surgery,Tibet Autonomous Region People′s Hospital,Lhasa 850000,China)

机构地区：[1]西藏自治区人民医院普通外科,西藏拉萨850000

出　　处：《基础医学与临床》2023年第9期1428-1431,共4页Basic and Clinical Medicine

基　　金：西藏自治区自然科学基金(XZ202001ZR0035G)。

摘　　要：目的探讨西藏地区藏族人群胆囊结石(GS)成分特点。方法收集2021年1月至6月于西藏自治区人民医院普通外科就诊的106例藏族患者的胆囊结石标本,采用紫外可见近红外光度计和电感耦合等离子体光谱仪分别测定胆囊结石中胆固醇、胆红素、胆酸的含量以及钙、硫、铁、锌元素的含量。结果106例胆囊结石中,8.49%(9例)为胆固醇类结石、胆固醇含量为534(528,725)μg/mg;19.81%(21例)为色素类结石、胆色素含量为320(311,413)μg/mg;71.69%(76例)为其他类型结石;同时在3种类型结石中均检测出含量不等的胆酸,在其他类结石中胆酸含量较高为22(12,33)μg/mg;色素类结石中钙、锌及硫元素含量相对较高(P<0.05),铁元素含量则无统计学意义。结论西藏地区藏族人群胆囊结石以其他类结石及胆色素类结石为主,胆固醇类结石占比小,与中国其他地方差异较大;色素类结石中钙、硫、锌元素含量相对均高,其中钙的含量最高。Objective To study the characteristics of gallstone composition in Tibetans.Methods Gallstone/gallbladder stone(GS)specimens were collected from 106 Tibetan patients in the Department of General Surgery of Tibet Autonomous Region People′s Hospital from January to June 2021.The contents of cholesterol,bilirubin,cholic acid and calcium,sulfur,iron and zinc in gallstone were determined by ultraviolet spectrophotometer and by inductively coupled plasma spectrometer.Results Among 106 cases of cholecystolithiasis,8.49%(9 cases)were cholesterol gallstones with cholesterol content of 534(528,725)μg/mg;19.81%(21 cases)were pigment stones,and the content of bile pigment was 320(311,413)μg/mg;71.69%(76 cases)were other types of stones;At the same time,bile acid with different contents was detected in three types of stones,and the content of bile acid in other types of stones was 22(12,33)μg/mg;The content of calcium,zinc and sulfur in pigment stone was relatively high(P<0.05),but the content of iron didn′t show had significant difference.Conclusions Gallstone of Tibetan people is mainly composed of other stones and pigment stones.Cholesterol stones only account for a small proportion,which is quite different from the composition profile from other parts of China.The content of calcium,sulfur and zinc in pigment stone is relatively high,and the content of calcium is the highest element.

关 键 词：西藏 胆囊结石病 成分分析 

分 类 号：R446.19[医药卫生—诊断学]