外泌体miRNAs在器官纤维化中作用的研究进展  

Progress on the role of exosomal miRNAs in organ fibrosis

作　　者：方路 刘睿奇 梁鹏[1] 岑瑛[2] FANG Lu;LIU Ruiqi;LIANG Peng;CEN Ying(Department of Day Surgery Center,General Practice Medical Center;Department of Burn and Plastic Surgery,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院全科医学中心日间手术中心,四川成都610041 [2]四川大学华西医院整形外科/烧伤科,四川成都610041

出　　处：《基础医学与临床》2023年第9期1472-1476,共5页Basic and Clinical Medicine

基　　金：四川省自然科学基金(2022NSFSC1395)。

摘　　要：外泌体是由多种细胞主动分泌产生的可携带蛋白质、脂质、miRNAs等生物分子的微小囊泡。外泌体微小RNAs(miRNAs)稳定的存在于体液循环中,参与器官多项病理过程。在器官纤维化疾病中,外泌体miRNAs的含量与正常组织相比呈现出明显的差异性表达,通过调控不同信号通路促进或抑制器官纤维化。外泌体miRNAs可作为临床诊断器官纤维化及判断其纤维化程度的最新生物指标和纤维化疾病新的治疗靶点。Exosomes are tiny vesicles that are actively secreted by a variety of cells,which regulate various physiological and pathological processes of the body by carrying proteins,lipids,miRNAs and other biological molecules.Exocrine microRNAs(miRNAs)stably exist in the body fluid circulation and participate in many pathological processes of organs.In organ fibrosis disease,the content of the exosomal miRNAs shows significant differential expression profile as compared with normal tissues,and promotes or inhibits organ fibrosis by regulating different signal pathways.It is considered to be the latest biological indicator for diagnosing organ fibrosis and judging its degree of fibrosis,and a new therapeutic target for fibrosis disease.

关 键 词：外泌体 外泌体miRNAs 纤维化疾病 

分 类 号：R33[医药卫生—人体生理学]