铁死亡在糖尿病肾脏疾病发病机制中的研究进展  

Research advances of ferroptosis in the pathogenesis of diabetic kidney disease

作　　者：李嘉欣 龙琴 李耀彰 李宪凯 王美峤 代巧妹[1] Li Jia-xin;Long Qin;Li Yao-zhang;Li Xian-kai;Wang Mei-Qiao;Dai Qiao-mei(College of Basic Medical Sciences,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学基础医学院,哈尔滨150040

出　　处：《临床肾脏病杂志》2023年第8期675-680,共6页Journal Of Clinical Nephrology

基　　金：中国博士后科学基金资助项目(2013M531081)。

摘　　要：铁死亡是近些年发现的一种新的细胞死亡方式,与坏死、凋亡、自噬等不同的是铁死亡是一种铁依赖性的脂质过氧化堆积后造成的结果。大量研究表明,糖尿病肾脏疾病发病与铁死亡有密切关系,多涉及铁离子代谢异常,脂质过氧化堆积,谷胱甘肽过氧化物酶4活性受到抑制及线粒体功能障碍等。本文围绕铁死亡的特点及调控铁死亡关键信号因子、关键信号通路与糖尿病肾脏疾病之间的关系以及近年靶向铁死亡对糖尿病肾脏疾病治疗的研究进展进行综述,旨在为临床糖尿病肾脏疾病防治提供参考。Ferroptosis is a novel mode of cell death discovered in recent years.Unlike necrosis,apoptosis or autophagy,ferroptosis is the result of iron-dependent lipid peroxidation accumulation.A growing number of studies have demonstrated that the pathogenesis of diabetic kidney disease(DKD)is correlated closely with ferroptosis,involving abnormal iron metabolism,an accumulation of lipid peroxidation,an inhibition of glutathione peroxidase 4 activity and mitochondrial dysfunction.This review summarized the characteristics of ferroptosis,the key signaling factors regulating ferroptosis,the relationship between key signaling pathways and DKD and the latest researches of targeting ferroptosis in the treatment of DKD,aiming to provide references for clinical prevention and treatment of DKD.

关 键 词：铁死亡 糖尿病肾病 谷胱甘肽过氧化物酶4 过氧化脂质类 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]