左西孟旦联合持续静注呋塞米对急性失代偿性心力衰竭患者血清可溶性基质溶素-2、神经元特异性稀醇化酶水平的影响  

Effect of Levosimendan combined with continuous static infusion of Fur-osemide on serum levels of soluble suppression of tumorigenicity-2,neuron-specific enolase in patients with acute decompensated heart failure

作　　者：李亚平 李海洋 郑高梅 LI Yaping;LI Haiyang;ZHENG Gaomei(Department of Cardiology,Fuyang People’s Hospital,Anhui Province,Fuyang 236000,China)

机构地区：[1]安徽省阜阳市人民医院心内科,安徽阜阳236000

出　　处：《中国医药导报》2023年第23期81-84,共4页China Medical Herald

基　　金：安徽省重点研究与开发计划项目(202004j07020014)。

摘　　要：目的研究左西孟旦联合持续静注呋塞米对急性失代偿性心力衰竭(ADHF)患者血清可溶性基质溶素-2(sST-2)、神经元特异性稀醇化酶(NSE)水平的影响。方法选取2019年1月至2020年10月在安徽省阜阳市人民医院进行诊治的140例ADHF患者,按照随机数字表法将其分为呋塞米组(持续静注呋塞米)、联合组(持续静注呋塞米+左西孟旦),各70例。两组均给予常规治疗,均治疗1周。比较治疗前后两组心率、左室短轴缩短率(LVFS)、左室射血分数(LVEF)、sST-2、NSE、氨基末端脑钠肽前体(NT-proBNP)、右房压(RAP)、肺毛细血管楔压(PCWP)及肺动脉平均压(PAMP)水平。比较两组不良反应发生率。结果治疗后,两组心率、sST-2、NSE、NT-proBNP、RAP、PCWP及PAMP均低于治疗前,LVFS、LVEF水平高于治疗前,且联合组心率、sST-2、NSE、NT-proBNP、RAP、PCWP及PAMP低于呋塞米组,LVFS、LVEF水平高于呋塞米组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论左西孟旦联合持续静注呋塞米对ADHF患者治疗效果显著,降低患者sST-2、NSE水平,改善患者血流动力学与心功能,值得临床推广。Objective To investigate the effects of Levosimendan combined with continuous static infusion Furosemide on serum levels of soluble suppression of tumorigehicity 2(sST-2)and neuron-specific enolase(NSE)in patients with acute decompensated heart failure(ADHF).Methods A total of 140 ADHF patients diagnosed and treated in Fuyang People’s Hospital of Anhui Province from January 2019 to October 2020 were selected and they were divided into Furosemide group(continuous static infusion Furosemide)and combination group(continuous static infusion Furosemide+Levosimendan)according to random number table method,with 70 cases in each group.Both groups were given conventional treatment and were treated for one week.The heart rate,left ventricular fractional shortening rate(LVFS),left ventricular ejection fraction(LVEF),sST-2,NSE,amino terminal brain natriuretic peptide precursor(NT-proBNP),right atrial pressure(RAP),pulmonary capillary wedge pressure(PCWP),and mean pulmonary artery pressure(PAMP)were compared between the two groups before and after treatment.The incidence of adverse reaction was compared between the two groups.Results After treatment,the heart rate,sST-2,NSE,NT-proBNP,RAP,PCWP,and PAMP in both groups were lower than before treatment,LVFS and LVEF levels were higher than before treatment and the heart rate,sST-2,NSE,NT-proBNP,RAP,PCWP,and PAMP in combination group were lower than those in Furosemide group,LVFS and LVEF levels were higher than those in Furosemide group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Levosimendan combined with continuous static infusion Furosemide has significant therapeutic effect on ADHF patients,reducing the levels of sST-2 and NSE,improving hemodynamics and cardiac function of patients,which is worthy of clinical promotion.

关 键 词：左西孟旦 呋塞米 急性失代偿性心力衰竭 神经元特异性稀醇化酶 

分 类 号：R540[医药卫生—心血管疾病]