亲环素A/CD147信号通路与新生儿缺氧缺血性脑损伤相关性研究进展  

Research progress in the relationship between cyclophilin A/CD147 signaling pathway and neonatal hypoxic-ischemic brain damage

作　　者：方芳[1] 严彩霞[1] 方成志[1] 张丙宏[1] FANG Fang;YAN Caixia;FANG Chengzhi;ZHANG Binghong(Department of Neonatology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China)

机构地区：[1]武汉大学人民医院新生儿科,湖北武汉430060

出　　处：《安徽医药》2023年第9期1706-1709,共4页Anhui Medical and Pharmaceutical Journal

基　　金：中央引导地方科技发展专项资金(鄂财教发〔2016〕109号);湖北省卫生健康委员会科研项目(WJ2019M84);五师科技计划项目(2019SF023)。

摘　　要：新生儿缺氧缺血性脑损伤(HIBD)是围产期窒息的严重并发症,影响着病儿的早期存活和远期预后。亲环素A(CypA)/CD147信号通路参与细胞的增殖、趋化、凋亡、炎症以及神经元代谢等过程,与HIBD的发生发展密切相关,因此研究CypA/CD147的作用机制对HIBD诊断与治疗具有重要意义。该研究阐述了CypA/CD147的信号通路与缺血缺氧性脑损伤关系最新研究进展,以期为HIBD的治疗提供新的思路与方向。Neonatal hypoxic-ischemic brain damage(HIBD)is a serious complication of perinatal asphyxia,affecting the early survival and long-term prognosis of the newborn.Cyclophilin A(CypA)/CD147 signaling pathway participates in the proliferation,chemotaxis,apoptosis,inflammation,neuronal metabolism and is closely related to the occurrence and development of HIBD.Therefore,the role mechanism of CypA/CD147 is important for HIBD diagnosis and treatment.This article reviews the latest research progress in the relationship between CypA/CD147 signaling pathway and hypoxic-ischemic brain damage,in order to provide a new idea and direction for the treatment of HIBD.

关 键 词：缺氧缺血 脑 亲环素A CD147 信号通路 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]