角质细胞生长因子对人工流产术后子宫内膜的修复作用及对月经转归、卵巢排卵的影响  

Repair effect of keratinocyte growth factor on the endometrium after induced abortion and its influence on menstrual regression and ovarian ovulation

作　　者：金立娟 户月 王丽 杜杰 任海霞 王宏卫 JIN Lijuan;HU Yue;WANG Li;DU Jie;REN Haixia;WANG Hongwei(Department of Gynecology,Shijiazhuang People's Hospital,Shijiazhuang,Hebei 050011,China;Department of Gynecology,Anping County People's Hospital,Hengshui,Hebei 053600,China)

机构地区：[1]石家庄市人民医院妇科,河北石家庄050011 [2]安平县人民医院妇科,河北衡水053600

出　　处：《安徽医药》2023年第9期1870-1873,共4页Anhui Medical and Pharmaceutical Journal

基　　金：河北省医学科学研究重点课题计划项目(20201414)。

摘　　要：目的探讨角质细胞生长因子(KGF)对人工流产术后子宫内膜的修复作用及对月经转归、卵巢排卵的影响。方法选取2019年12月至2020年12月在石家庄市人民医院行人工流产术的早孕妇女120例,将所有孕妇按随机数字表法分为观察组60例,对照组60例,对照组采用玻璃酸钠治疗,观察组采用KGF治疗,观察并统计两组的阴道出血天数和月经复潮时间,采用彩色多普勒超声诊断仪对两组子宫动脉阻力指数、血流量、搏动指数、收缩末期血流峰值/舒张末期血流峰值(S/D)、平均流速血流动力学参数进行测评,采用腹部B超检查两组的子宫内膜厚度变化情况,统计两组的卵巢恢复排卵例数。B超检查两组的宫腔粘连程度。结果观察组阴道出血天数(4.62±0.23)d和月经复潮时间(28.12±2.06)d均短于对照组(6.23±0.55)d、(34.12±2.16)d(P<0.05);治疗后,对照组阻力指数、搏动指数、血流量、平均流速、S/D均显著降低(P<0.05),且观察组治疗后上述指标均高于对照组(P<0.05);观察组子宫内膜厚度(9.36±1.09)mm大于对照组(6.22±1.11)mm(P<0.05);观察组卵巢恢复排卵例数22例多于对照组6例(P<0.05);观察组宫腔粘连程度低于对照组(P<0.05)。结论KGF治疗可有效改善人工流产术后月经转归情况,稳定术后血流动力学,促进子宫内膜修复和卵巢排卵功能的恢复。Objective To investigate the effect of keratinocyte growth factor(KGF)on the repair of the endometrium after induced abortion and its effect on menstrual regression and ovarian ovulation.Methods A total of 120 early pregnant women who underwent induced abortion in Shijiazhuang People's Hospital from December 2019 to December 2020 were selected.All pregnant women were randomly divided into 60 cases in the observation group and 60 cases in the control group according to the random number table method.The control group was treated with sodium hyaluronate and the observation group was treated with KGF.The number of days of vaginal bleeding and the time of menstrual rehydration in the two groups were observed and counted.The uterine artery resistance index,blood flow,pulsatility index,peak end-systolic blood flow/peak end-diastolic blood flow(S/D),and mean flow hemodynamic parameters of the two groups were measured by using color Doppler ultrasonography.The changes in endometrial thickness of the two groups were examined using abdominal B-ultrasound,and the number of cases of ovarian ovulation recovery in the two groups was counted.The degree of intrauterine adhesion in the two groups was examined by B-ultrasound.Results The number of days of vaginal bleeding(4.62±0.23)d and the time of menstrual resumption(28.12±2.06)d in the observation group were shorter than those in the control group[(6.23±0.55)d and(34.12±2.16)d,respectively](P<0.05).After treatment,the resistance index,pulsatility index,blood flow rate,mean flow rate,and S/D were all significantly reduced in the control groups(P<0.05),and all of the above indicators were higher in the observation group than in the control group(P<0.05).The endometrial thickness of the observed group(9.36±1.09)mm was greater than that of the control group(6.22±1.11)mm(P<0.05);the number of ovarian recovery ovulation cases in the observation group was 22 cases more than that of the control group(6 cases)(P<0.05);and the degree of intrauterine adhesion in the observation gro

关 键 词：角质细胞生长因子 排卵 人工流产术 子宫内膜 月经转归 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]