儿童脓毒症病理生理特征及早期诊断生物学标志物的研究进展  

Research progress on pathophysiological characteristics and early diagnostic biomarkers of pediatric sepsis

作　　者：杨雨薇 武荣[2] 苗业权 林小飞[1] YANG Yuwei;WU Rong;MIAO Yequan;LIN Xiaofei(Department of Pediatrics,Huai'an Maternal and Child Health Hospital Affiliated to Yangzhou University Medical College,Jiangsu Province,Huai'an,223002,China;Department of Neonatology,Huai'an Maternal and Child Health Hospital Affiliated to Yangzhou University Medical College,Jiangsu Province,Huai'an,223002,China)

机构地区：[1]扬州大学医学院附属淮安市妇幼保健院儿科,江苏淮安223002 [2]扬州大学医学院附属淮安市妇幼保健院新生儿科,江苏淮安223002

出　　处：《中国当代医药》2023年第24期31-36,共6页China Modern Medicine

基　　金：江苏省卫生健康委科研项目(LGY2018044);江苏省淮安市科技项目(HAB201825)。

摘　　要：脓毒症是宿主对感染的失调反应而引起的危及生命的器官功能障碍,目前沿用脓毒症3.0定义。儿童脓毒症是一种具有高发病率、高致残率和高死亡率的儿童临床常见危重症,随着病情加重可进展为脓毒性休克、多器官功能障碍等。该综述简述了脓毒症的定义以及器官功能障碍、机体免疫功能和细胞功能障碍、机体代谢变化、机体微循环变化等病理生理变化,并概括相关的儿童脓毒症早期诊断生物学标志物,为儿童脓毒症临床诊治策略制定、病情评估、病程监测和预后判断提供思路。Sepsis is a life-threatening organ dysfunction caused by the host's dysfunctional response to infection,currently defined as sepsis 3.0.Pediatric sepsis is a common clinical critical disease with high incidence rate,high disability rate and high mortality.With the aggravation of the disease,it can progress to septic shock,multiple organ dysfunction,etc.This review outlines the definition of sepsis and pathological and physiological changes such as organ dysfunction,immune and cellular dysfunction,metabolic changes,and microcirculation changes,and summarizes the relevant biomarkers for early diagnosis of pediatric sepsis,provides ideas for clinical diagnosis and treatment strategies,condition evaluation,disease course monitoring,and prognosis judgment of pediatric sepsis.

关 键 词：儿童 脓毒症 病理生理 机制 早期诊断 生物学标记物 

分 类 号：R720.597[医药卫生—急诊医学]