IL-33参与2型炎症瘙痒的神经免疫机制研究进展  

Neuroimmune mechanisms of IL-33 involved in type 2 inflammatory pruritus

作　　者：周灵萱 赵洋 袁晓辉 徐哲 刘玲玲[1] 汪旸[1] 赵嘉惠[1] ZHOU Lingxuan;ZHAO Yang;YUAN Xiaohui;XU Zhe;LIU Lingling;WANG Yang;ZHAO Jiahui(Department of Dermatology,Peking University First Hospital&Beijing Key Laboratory of Molecular Diagnosis on Dermatoses&National Clinical Research Center for Skin and Immune Disease&NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics,Beijing 100034,China;Shunyi Maternal and Children s Hospital of Beijing Children s Hospital,Beijing 101300,China;Department of Dermatology,Beijing Children s Hospital,Capital Medical University&National Center for Children s Health,Beijing 100045,China)

机构地区：[1]北京大学第一医院皮肤性病科&国家皮肤与免疫疾病临床医学研究中心&皮肤病分子诊断北京市重点实验室&国家药品监督管理局化妆品质量控制与评价重点实验室,北京100034 [2]北京市顺义区妇幼保健院,北京儿童医院顺义妇儿医院,北京101300 [3]国家儿童医学中心,首都医科大学附属北京儿童医院皮肤科,北京100045

出　　处：《中国麻风皮肤病杂志》2023年第9期688-692,共5页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金青年项目(编号:81903213);北京脑科学与类脑研究中心科研合作开放基金项目(编号:2020-NKX-XM-08)。

摘　　要：IL-33是白细胞介素1家族来源的核细胞因子,通过其受体作用于多种细胞,如肥大细胞、2型固有淋巴细胞、嗜碱性粒细胞,是2型免疫反应发生及维持的重要细胞因子之一。近年来研究表明,IL-33激活外周神经系统参与瘙痒信号的传递。本文回顾了IL-33介导受体激活的信号转导机制/2型炎症皮肤病中IL-33参与瘙痒的神经免疫机制及IL-33靶向药物研究进展。IL-33 is a nuclear cytokine of the IL-1 family,which acts on a variety of cells through combination its receptors,such as mast cells,innate lymphocytes type 2,basophils,etc..It is one of the important cytokines in the development and maintenance of type 2 immune responses.Recent studies have shown that IL-33 is involved in pruritic signaling through activating the peripheral nervous system.This paper focuses on the signal transduction mechanism after the activation of interleukin 33 receptor,and elaborates the neuroimmune mechanism of IL-33 involved in pruritus in type 2 inflammatory skin diseases.We also review the advances of drug research targeting IL-33.

关 键 词：IL-33 瘙痒 2型炎症 神经免疫 

分 类 号：R751[医药卫生—皮肤病学与性病学]