2020年天津市滨海新区健康人群麻疹、腮腺炎、风疹抗体水平监测分析  

Monitoring and Analysis of Measles,Mumps and Rubella Antibody Levels Among Healthy People in Binhai New Area of Tianjin in 2020

作　　者：郝宝云 卢慧子 邵红梅 张金玲 任亮 王丽娟 裴亚楠 李晓青 HAO Bao-yun;LU Hui-zi;SHAO Hong-mei;ZHANG Jin-ling;REN Liang;WANG Li-juan;PEI Ya-nan;LI Xiao-qing(Immune Planning Department of Tianjin Binhai New Area Disease Prevention and Control Center,Tianjin 300457,China)

机构地区：[1]天津市滨海新区疾病预防控制中心免疫规划科,天津300457

出　　处：《医学信息》2023年第17期60-63,共4页Journal of Medical Information

摘　　要：目的了解2020年天津市滨海新区健康人群麻疹、腮腺炎和风疹的抗体水平和分布情况,探索性比较三者抗体水平的衰减特点。方法采用横断面调查方法在天津市滨海新区抽取0~44岁健康人群采集血清样本,采用酶联免疫吸附试验检测麻疹、腮腺炎和风疹IgG抗体,分析几何平均浓度(GMC)、抗体阳性率情况。结果滨海新区健康人群麻疹GMC为801 mIU/ml,抗体阳性率为85.86%;腮腺炎GMC为337 U/ml,抗体阳性率为81.38%;风疹GMC为48 IU/ml,抗体阳性率为81.72%;不同年龄、含麻疫苗接种剂次、距末次含麻疫苗接种时间健康人群麻疹IgG抗体阳性率和GMC比较,差异有统计学意义(P<0.05);不同性别、年龄、年龄、含腮腺炎疫苗接种剂次、距末次含腮腺炎疫苗接种时间健康人群腮腺炎IgG抗体阳性率、GMC比较,差异有统计学意义(P<0.05);不同年龄、不同含风疹疫苗接种剂次、距末次含风疹疫苗接种时间健康人群风疹IgG抗体阳性率、GMC比较,差异有统计学意义(P<0.05)。结论天津市滨海新区2020年健康人群麻疹、腮腺炎和风疹抗体水平总体偏低,其中与麻疹和风疹相比,腮腺炎抗体持续时间更长。在此基础上,应综合考虑麻疹、风疹和腮腺炎母传抗体衰减特点、疾病自然感染产出的抗体衰减特点、疾病负担,积极探索MMR成人包括育龄期妇女免疫策略在我国施行的可行性和成本效益比。Objective To understand the antibody levels and distribution of measles,mumps and rubella in healthy people in Binhai New Area of Tianjin in 2020,and to explore the attenuation characteristics of the antibody levels of the three.Methods The cross-sectional survey method was used to collect serum samples from healthy people aged 0-44 years in Binhai New Area of Tianjin.The IgG antibodies against measles,mumps and rubella were detected by enzyme-linked immunosorbent assay.The geometric mean concentration(GMC)and antibody positive rate were analyzed.Results For healthy population in Binhai New Area,the GMC of measles was 801 mIU/ml,and the positive rate of antibody was 85.86%;the GMC of mumps was 337 U/ml,and the antibody positive rate was 81.38%;the GMC of rubella was 48 IU/ml,and the antibody positive rate was 81.72%.There were statistically significant differences in the positive rate of IgG antibody and GMC among healthy people of different ages,doses of measles-containing vaccine,and time from the last time of measles-containing vaccine inoculation(P<0.05).There were statistically significant differences in the positive rate of mumps IgG antibody and GMC among healthy people with different genders,ages,ages,doses of mumps vaccination,and time from the last mumps vaccination(P<0.05).There were statistically significant differences in rubella IgG antibody positive rate and GMC among healthy people of different ages,different doses of rubella vaccination,and time from the last rubella vaccination(P<0.05).Conclusion The antibody levels of measles,mumps and rubella in healthy population in Binhai New Area of Tianjin in 2020 are generally low,and the duration of mumps antibody is longer than that of measles and rubella.On this basis,we should comprehensively consider the characteristics of maternal antibody attenuation of measles,rubella and mumps,the characteristics of antibody attenuation of natural infection output of the disease,and the burden of disease to actively explore the feasibility and cost-effectiveness

关 键 词：麻疹 腮腺炎 风疹 健康人群抗体 

分 类 号：R446.6[医药卫生—诊断学]