血sST2浓度联合MLR水平对冠心病患者MACE事件的预测价值  

The Predictive Value of Serum sST2 Concentration Combined with MLR Level for MACE Events in Patients with Coronary Heart Disease

作　　者：刘晓丹 尚士梅 林先和[1] LIU Xiao-dan;SHANG Shi-mei;LIN Xian-he(Department of Cardiology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China;Graduate School of Anhui Medical University,Hefei 230032,Anhui,China)

机构地区：[1]安徽医科大学第一附属医院心内科,安徽合肥230022 [2]安徽医科大学研究生学院,安徽合肥230032

出　　处：《医学信息》2023年第17期123-126,137,共5页Journal of Medical Information

基　　金：安徽省自然科学基金资助项目(编号:2008085MH239)。

摘　　要：目的探讨血可溶性致瘤性抑制蛋白2(sST2)浓度联合单核细胞/淋巴细胞比率(MLR)水平对冠心病患者主要不良心血管事件(MACE)的预测价值。方法选取2021年3月-2022年2月就诊于安徽医科大学第一附属医院心血管内科且符合ACCF/AHA指南中冠心病诊断标准的121例患者,根据是否发生MACE事件发生分为MACE事件(+)组(n=39)和MACE事件(-)组(n=82)。采用单因素及多因素二元Logistic回归分析影响MACE事件发生的危险因素,采用受试者工作特征(ROC)曲线描述血sST2浓度联合MLR水平对MACE事件的预测价值。结果两组性别、年龄、BMI、吸烟史、饮酒史、高血压史、糖尿病史、PCI病史、TC、TG、n-HDL、HDL-C、LDL-C、LPa比较,差异无统计学意义(P>0.05);两组NLR、MLR、BNP、LVEF、LVD、sST2比较,差异有统计学意义(P<0.05)。多因素二元Logistic回归分析结果显示,sST2、MLR水平为发生MACE事件的影响因素(P<0.05)。ROC曲线分析显示,sST2联合MLR预测MACE事件的AUC为0.817。结论血清sST2联合MLR对冠心病患者MACE事件有一定的预测价值。Objective To investigate the predictive value of soluble suppression of tumorigenicity 2(sST2)combined with monocyte/lymphocyte ratio(MLR)level on major adverse cardiovascular events(MACE)in patients with coronary heart disease(CHD).Methods A total of 121 patients who were admitted to the Department of Cardiology,the First Affiliated Hospital of Anhui Medical University from March 2021 to February 2022 and met the diagnostic criteria of coronary heart disease in the ACCF/AHA guidelines were selected.According to the occurrence of MACE events,they were divided into MACE event(+)group(n=39)and MACE event(-)group(n=82).Univariate and multivariate binary Logistic regression analysis were used to analyze the risk factors affecting the occurrence of MACE events.The receiver operating characteristic(ROC)curve was used to describe the predictive value of blood sST2 concentration combined with MLR level for MACE events.Results There was no significant difference in gender,age,BMI,smoking history,drinking history,hypertension history,diabetes history,PCI history,TC,TG,n-HDL,HDL-C,LDL-C and LPa between the two groups(P>0.05),while there were significant differences in NLR,MLR,BNP,LVEF,LVD and sST2 between the two groups(P<0.05).Multivariate binary Logistic regression analysis showed that sST2 and MLR levels were the influencing factors of MACE events(P<0.05).ROC curve analysis showed that the AUC of sST2 combined with MLR in predicting MACE events was 0.817.Conclusion sST2 combined with MLR has a certain predictive value in patients with coronary heart disease.

关 键 词：冠心病 可溶性致瘤性抑制蛋白2 单核细胞/淋巴细胞 主要不良心血管事件 

分 类 号：R543.5[医药卫生—心血管疾病]