康复新液预防抗结核药品消化道不良反应的效果  

Effect of Kangfuxin Liquid on Prevention of Gastrointestinal Adverse Reactions of Anti-tuberculosis Drugs

作　　者：丁华 DING Hua(Department of Chronic Diseases,Linchuan District Center for Disease Control and Prevention,Fuzhou 344100,Jiangxi,China)

机构地区：[1]抚州市临川区疾病预防控制中心慢病科,江西抚州344100

出　　处：《医学信息》2023年第17期157-160,共4页Journal of Medical Information

摘　　要：目的探究康复新液对抗结核药品引起消化道不良反应的预防作用。方法选取2021年1月-2022年6月抚州市临川区疾病预防控制中心收治的80例结核病患者,按照随机数字表法分为对照组(40例)和观察组(40例)。对照组给予常规抗结核药品治疗,观察组在其基础上加用康复新液治疗。比较两组消化道不良反应发生情况(恶心、呕吐、食欲不振、腹泻等)、胃肠道症状分级量表(GSRS)评分、化疗消化道症状量表(C-GITSI)评分、血清炎症因子[肿瘤坏死因子(TNF-α)、白介素(IL-1)、C-反应蛋白(CRP)]、世界卫生组织生存质量测定表简表(WHOQOL-BREF)评分。结果观察组消化道不良反应发生率小于对照组(P<0.05);两组治疗后GSRS、C-GITSI评分均高于治疗前,但观察组GSRS、C-GITSI评分低于对照组(P<0.05);两组治疗后TNF-α、IL-1、CRP水平低于治疗前,且观察组TNF-α、IL-1、CRP水平低于对照组(P<0.05);两组治疗后WHOQOL-BREF评分高于治疗前,且观察组WHOQOL-BREF评分高于对照组(P<0.05)。结论康复新液可减少抗结核药品引起的消化道不良反应,同时缓解其症状严重程度,可抑制机体炎症反应,有助于患者生存质量的提升。Objective To explore the preventive effect of Kangfuxin Liquid on gastrointestinal adverse reactions caused by anti-tuberculosis drugs.Methods A total of 80 patients with tuberculosis admitted to Linchuan District Center for Disease Control and Prevention of Fuzhou City from January 2021 to June 2022 were selected and divided into control group(40 patients)and observation group(40 patients)according to random number table method.The control group was treated with conventional anti-tuberculosis drugs,and the observation group was treated with Kangfuxin liquid on the basis of the control group.The incidence of gastrointestinal adverse reactions(nausea,vomiting,loss of appetite,diarrhea,etc.),Gastrointestinal Symptom Rating Scale(GSRS)score,Chemotherapy Gastrointestinal Symptom Scale(C-GITSI)score,serum inflammatory factors[tumor necrosis factor(TNF-α),interleukin(IL-1),C-reactive protein(CRP)],World Health Organization Quality of Life-BREF(WHOQOL-BREF)score were compared between the two groups.Results The incidence of gastrointestinal adverse reactions in the observation group was lower than that in the control group(P<0.05).After treatment,the GSRS and C-GITSI scores of the two groups were higher than those before treatment,but the GSRS and C-GITSI scores of the observation group were lower than those of the control group(P<0.05).After treatment,the levels of TNF-α,IL-1 and CRP in the two groups were lower than those before treatment,and the levels of TNF-α,IL-1 and CRP in the observation group were lower than those in the control group(P<0.05).The WHOQOL-BREF score of the two groups after treatment was higher than that before treatment,and the WHOQOL-BREF score of the observation group was higher than that of the control group(P<0.05).Conclusion Kangfuxin liquid can reduce the gastrointestinal adverse reactions caused by anti-tuberculosis drugs,alleviate the severity of symptoms,inhibit the body's inflammatory response,and help improve the quality of life of patients.

关 键 词：抗结核治疗 康复新液 消化道不良反应 炎症反应 生存质量 

分 类 号：R52[医药卫生—内科学]