AFP-L3、GP73、HBV-DNA水平于肝癌中的诊断价值分析  

Diagnostic Value of AFP-L3,GP73 and HBV-DNA Levels in Liver Cancer

作　　者：邓存文 DENG Cunwen(Department of Hepatobiliary Surgery,Jiuquan People´s Hospital,Jiuquan,Gansu Province,735099 China)

机构地区：[1]酒泉市人民医院肝胆外科,甘肃酒泉735099

出　　处：《系统医学》2023年第11期143-145,154,共4页Systems Medicine

摘　　要：目的 分析甲胎蛋白异质体(alpha fetoprotein heterogene-L3, AFP-L3)、高尔基体糖蛋白73(Golgi glycoprotein73, GP73)、乙型病毒性肝炎DNA(hepatitis B virus DNA, HBV-DNA)水平在肝癌中的诊断价值。方法回顾性分析2018年1月-2020年11月酒泉市人民医院收治的41例肝癌患者为肝癌组,19例肝硬化患者为肝硬化组,以及同期纳入体检健康者60例的临床资料为对照组。分别检测3组的AFP-L3、GP73、HBV-DNA含量,并分析HBV-DNA与AFP-L3、GP73各项指标单独检测结果和诊断效能。结果 对照组的AFP-L3、GP73、HBV-DNA分别为(2.56±0.58)μg/L、(47.13±8.14)μg/L、(76.78±12.13)log copies/mL均明显低于肝硬化组及肝癌组,而肝硬化组上述指标低于肝癌组,差异有统计学意义(P<0.05);AFP-L3、GP73、HBV-DNA联合诊断肝癌的敏感度(92.68%)、特异性(89.47%)、准确度(91.67%)高于各项指标单独检测,差异有统计学意义(P<0.05)。结论 AFP-L3、GP73、HBV-DNA联合检测对提高肝癌检出率和肝癌的早期诊断具有重要意义,可在临床推广运用。Objective To analyze diagnostic value of alpha fetoprotein heterogene-L3(AFP-L3),Golgi glycoprotein73(GP73),hepatitis B virus DNA(HBV-DNA)in liver cancer.Methods Retrospectively analysed of 41 liver cancer pa⁃tients admitted to Jiuquan People´s Hospital from January 2018 to November 2020 as the liver cancer group,19 liver cirrhosis patients as the liver cirrhosis group,and clinical data of 60 healthy individuals included in the same period as the control group.Detected the AFP-L3,GP73,and HBV-DNA content of three groups of subjects,and analyzed the individual detection results and diagnostic efficacy of HBV-DNA and AFP-L3,GP73 indicators.Results The AFP-L3,GP73,and HBV-DNA of the control group were(2.56±0.58)μg/L,(47.13±8.14)μg/L and(76.78±12.13)log copies/mL respectively,were significantly lower than those in the liver cirrhosis group and liver cancer group,while the above indicators in the liver cirrhosis group were lower than those in the liver cancer group,the difference was statistically significant(P<0.05).The sensitivity(92.68%),specificity(89.47%),and accuracy(91.67%)of the combined diagnosis of AFP-L3,GP73,and HBV-DNA for liver cancer were higher than those of individual detection of various indicators,and the difference was statistically significant(P<0.05).Conclusion The combined detection of AFP-L3,GP73 and HBV-DNA is of great significance to improve the detection rate of liver cancer and the early diag⁃nosis of liver cancer,and can be popularized in clinical application.

关 键 词：肝癌 甲胎蛋白异质体 乙型肝炎DNA 高尔基体糖蛋白7 诊断率 

分 类 号：R12[医药卫生—环境卫生学]