内镜下联合治疗肝硬化并发食管胃底静脉曲张破裂出血的临床效果分析  

Clinical Effect of Endoscopic Combined Treatment of Liver Cirrhosis Complicated with Esophageal and Gastric Varices Rupture and Bleeding

作　　者：涂建军[1] 李翠玉 王鹏飞 TU Jianjun;LI Cuiyu;WANG Pengfei(Department of Gastroenterology,Nanping First Hospital,Nanping,Fujian Province,353000 China)

机构地区：[1]福建省南平市第一医院消化内科,福建南平353000

出　　处：《中外医疗》2023年第19期61-64,共4页China & Foreign Medical Treatment

摘　　要：目的 探讨肝硬化并发食管胃底静脉曲张破裂出血患者运用内镜下联合方案展开治疗的效果。方法方便选取2019年1月—2021年12月福建省南平市第一医院肝硬化并发食管胃底静脉曲张破裂出血患者150例,采用数字表抽取法随机分组,其中,对照组75例运用生长抑素给药方案,观察组75例运用内镜下联合给药方案,就两组总有效率、止血及住院时间、肝功能指标、血流动力学指标、不良反应发生率展开对比。结果观察组患者总有效率为97.33%,相较对照组80.00%高,差异有统计学意义(χ^(2)=11.212,P<0.05)。观察组止血时间、住院时间短于对照组,差异有统计学意义(P<0.05)。治疗后观察组ALT,AST水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 针对临床收治的肝硬化伴有食管胃底静脉曲张破裂出血患者,运用内镜下联合方案施以治疗,可提高总有效率,缩短止血及住院时间,增强肝功能,改善血流动力学水平,且具更高安全性,开展价值显著。Objective To investigate the effect of endoscopic combined therapy in patients with cirrhosis and esophageal variceal hemorrhage.Methods A total of one hundred and fifty patients with cirrhosis accompanied by esophageal variceal hemorrhage admitted to Nanping First Hospital from January 2019 to December 2021were conveniently selected,and grouped randomly by digital table extraction method.Among them,seventy-five cases in the control group were treated with somatostatin administration,and seventy-five cases in the observation group were treated with endoscopic combined administration.The total effective rate,hemostasis and hospital stay,liver function index,hemodynamic index and adverse reaction incidence rate were compared between the two groups.Results The total effective rate of patients in the observation group was 97.33%,higher than 80.00%in the control group,and the difference was statistically significant(χ^(2)=11.212,P<0.05).The hemostatic time and hospital stay of the observation group were shorter than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the ALT and AST levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between two groups(P>0.05).Conclusion For patients with cirrhosis and esophageal and gastric variceal rupture and bleeding in clinical treatment,endoscopic combined treatment can improve the total effective rate,shorten hemostasis and hospital stay,enhance liver function,improve hemodynamics,and have higher safety and significant development value.

关 键 词：肝硬化 食管胃底静脉曲张破裂出血 生长抑素 内镜下联合方案 

分 类 号：R5[医药卫生—内科学]