血清胆汁酸水平与2型糖尿病的相关性研究  

Study on the Correlation Between Serum Bile Acid Level and Type 2 Diabetes Mellitus

作　　者：陈丽君 林家煜[1] 蔡清颜[1] 杨鑫娜[1] CHEN Lijun;LIN Jiayu;CAI Qingyan;YANG Xinna(Department of Endocrinology,the Second Affiliated Hospital of Fujian Medical University,Quanzhou,Fujian Province,362000 China)

机构地区：[1]福建医科大学附属第二医院内分泌科,福建泉州362000

出　　处：《糖尿病新世界》2023年第13期194-198,共5页Diabetes New World Magazine

摘　　要：2型糖尿病(type 2 diabetes mellitus, T2DM)作为一种代谢性疾病,已经成为继肿瘤、心血管病变之后第三大严重威胁人类健康的慢性疾病。糖尿病临床表型中以T2DM为主。T2DM发病机制相对复杂,目前认为胰岛β细胞功能缺陷、胰岛素抵抗是2型糖尿病发生的主要原因。同时糖尿病患者更易引起血脂、脂蛋白异常,增加各种糖尿病并发症的风险。有研究表明糖尿病患者常伴有总胆汁酸池的增加和胆汁酸成分的改变。胆汁酸除了在膳食脂肪的吸收和胆固醇的稳态中发挥作用,还参与许多信号通路的调控。此外,胆汁酸还通过调节自身的肝肠循环,维持三酰甘油、胆固醇的平衡,并参与能量和血糖水平的调控。本文主要针对血清胆汁酸与2型糖尿病的关系及其研究进展进行综述。As a metabolic disease,type 2 diabetes mellitus(T2DM)has become the third chronic disease that seriously threatens human health after tumors and cardiovascular diseases.The clinical phenotype of diabetes is dominated by T2DM.The pathogenesis of T2DM is relatively complex.At present,it is believed that the functional defect of isletβcells and insulin resistance are the main causes of type 2 diabetes.At the same time,diabetic patients are more likely to cause abnormal blood lipids and lipoproteins,increasing the risk of various diabetic complications.Studies have shown that diabetic patients are often accompanied by an increase in the total bile acid pool and changes in bile acid composition.In addition to their roles in dietary fat absorption and cholesterol homeostasis,bile acids are also involved in the regulation of many signaling pathways.In addition,bile acids also maintain the balance of triglyceride and cholesterol by regulating their own enterohepatic circulation,and participate in the regulation of energy and blood sugar levels.This paper mainly reviews the relationship between serum bile acid and type 2 diabetes and its research progress.

关 键 词：胆汁酸 糖尿病 法尼醇X受体 G蛋白偶联胆汁酸受体 

分 类 号：R587[医药卫生—内分泌]