In vivo imaging of the neuronal response to spinal cord injury:a narrative review  

作　　者：Junhao Deng Chang Sun Ying Zheng Jianpeng Gao Xiang Cui Yu Wang Licheng Zhang Peifu Tang 

机构地区：[1]Department of Orthopedics,The Fourth Medical Center of Chinese PLA General Hospital [2]National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation [3]School of Life Sciences,Tsinghua University [4]Department of Orthopedics,Air Force Medical Center,PLA [5]Medical School of Chinese PLA [6]Institute of Orthopedics,The First Medical Center,Chinese PLA General Hospital [7]Key Lab of Regenerative Medicine in Orthopedics,Key Laboratory of Musculoskeletal Trauma and War Injuries PLA

出　　处：《Neural Regeneration Research》2024年第4期811-817,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.82272478(to PT)。

摘　　要：Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury(SCI).However,this subject has been neglected in part because appropriate tools are lacking.Emerging in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and disease.This review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques,and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to SCI.We then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience examinations.Finally,we identify the challenges and possible solutions for spinal cord neuron imaging.

关 键 词：anterior horn neurons calcium imaging central nervous system dorsal horn neurons dorsal root ganglion in vivo imaging neuronal response spinal cord injury spinal cord two-photon microscopy 

分 类 号：R651.2[医药卫生—外科学]