基于金属卡宾的形式[4+1]环化反应  

Formal[4+1]annulations based on metal carbenes

作　　者：陈灿明 孔胤铸 钱鹏程[2] 周波[1] 叶龙武[1,3] Can-Ming Chen;Yin-Zhu Kong;Peng-Cheng Qian;Bo Zhou;Long-Wu Ye(College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China;College of Chemistry&Materials Engineering,Wenzhou University,Wenzhou 325035,China;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China)

机构地区：[1]厦门大学化学化工学院,厦门361005 [2]温州大学化学与材料工程学院,温州325035 [3]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032

出　　处：《中国科学：化学》2023年第8期1377-1388,共12页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:22125108,92056104)资助项目。

摘　　要：金属卡宾参与的有机化学转化被认为是均相催化中最重要的研究方向之一.过渡金属催化的卡宾转化为多种环状化合物的高效构建提供了快速手段,一系列小环、中环及大环化合物可被方便地合成得到.由于五元环状化合物的广泛用途,人们开发了各类基于金属卡宾的形式[4+1]环化反应.根据金属卡宾的产生方式来分类,本文分别从重氮途径以及非重氮途径介绍了各类环化策略的设计思路、适用范围、反应机理、潜在应用及各自的优缺点.Metal carbene-involved organic transformations are considered as one of the most important aspects in homogeneous transition-metal catalysis.Transition-metal catalyzed transformations of carbenes provide facile access towards divergent cyclic compounds,and a series of small-,medium-and large-sized rings were synthesized conveniently.Due to the wide applications of five-membered rings,various formal[4+1]annulations were established employing metal carbenes.Based on the methods of carbene formation,including diazo involved and non-diazo involved methodologies,this review introduces the designs,scopes,reaction mechanisms,potential applications,as well as the advantages and disadvantages of each synthetic strategy.

关 键 词：金属卡宾 环化反应 重氮化合物 五元环 

分 类 号：O621.251[理学—有机化学]