高血压患者黄斑区视网膜脉络膜厚度变化及脉络膜厚度影响因素分析  

Changes of Retinal and Choroidal Thickness in Macular Area in Patients with Hypertension and Analysis of Factors Related to Choroid Thickness

作　　者：李利 许雪妹[1] 郭淑玲[1] 钟永芳 张媛梅[1] 王海彬[1] LI Li;XU Xue-mei;GUO Shu-ling;ZHONG Yong-fang;ZHANG Yuan-mei;WANG Hai-bin(Department of Ophthalmology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China)

机构地区：[1]承德医学院附属医院眼科,承德067000

出　　处：《微循环学杂志》2023年第3期39-45,共7页Chinese Journal of Microcirculation

基　　金：河北省承德市科技局指导项目(202204A032)。

摘　　要：目的:观察高血压患者黄斑区视网膜和脉络膜厚度的变化;探讨高血压性视网膜病变的危险因素。方法:采用横断面研究,收集2020-12-2022-12本院眼科门诊就诊的62例(105眼)高血压患者为高血压组,其中男30例53眼,女32例52眼。收集同期28例(56眼)无高血压的健康者作为对照组,其中男14例28眼,女14例28眼。使用SD-OCT中自带的EDI模式,以黄斑中心凹为中心,测量直径为1mm范围内(中心凹区)、1-3mm范围内(内环区:上方、下方、颞侧及鼻侧四个分区)及3-6mm范围内(外环区:上方、下方、颞侧及鼻侧四个分区)的平均视网膜厚度及脉络膜厚度,比较两组各分区平均视网膜厚度及脉络膜厚度的差异,分析黄斑中心凹下脉络膜厚度的影响因素。结果:除黄斑中心凹和内环上方外,高血压组黄斑区视网膜厚度较对照组变薄(P<0.05或P<0.01)。高血压组黄斑区脉络膜厚度较对照组变薄(P<0.01)。回归分析发现黄斑中心凹下脉络膜厚度与年龄和收缩压呈负相关关系(P<0.05或P<0.01)。结论:高血压患者年龄及血压水平影响视网膜及脉络膜微循环。Objective:To observe the changes of retinal and choroidal thickness in the macular area in patients with hypertension and investigate the risk factors of hypertensive retinopathy.Method:A total of 105 eyes of 62 patients with hypertension were recruited from December 2020 to December 2022 in hypertensive group,including 53 eyes of 30 males and 52 eyes of 32 females.Another 56 eyes of 28 healthy subjects without hypertension were collected in control group,including 28 eyes of 14 males and 28 eyes of 14 females.With the fovea of macula as the center,the EDI pattern with spectral domain optical coherence tomography(SD-OCT)was used to measure the mean retinal thickness and choroidal thickness in the foveal region with a diameter of 1 mm(foveal region),1-3 mm(inner macula regions:superior,inferior,temporal,and nasal),and 3-6 mm(outer macula regions:superior,inferior,temporal,and nasal).The differences of mean retinal thickness and choroidal thickness between the two groups were compared.The influencing factors of subfoveal choroidal thickness were analyzed.Results:Except for the fovea and inner macula regions superior,the retinal thickness in the macular area in the hypertensive group became thinner compared with the control group(P<0.05 or P<0.01).The choroidal thickness in the macular area in the hypertensive group became thinner compared with the control group(P<0.01).Regression analysis revealed that there was a negative correlation between the subfoveal choroidal thickness and age and systolic blood pressure(P<0.05 or P<0.01).Conclusion:Age and blood pressure may have an effect on microcirculation of retina and choroid in patients with hypertension.

关 键 词：高血压 频域光学相干断层扫描 黄斑区 视网膜厚度 脉络膜厚度 

分 类 号：R544.1[医药卫生—心血管疾病]