骨碎补总黄酮调控骨质疏松症分子机制研究进展  

Research Progress on Molecular Mechanism of Total Flavones of Rhizoma drynariae Regulating Osteoporosis

作　　者：梁健[1] 伍亮[2] 苏睿 宋泉生[2] 陈飞虎 LIANG Jian;WU Liang;SU Rui;SONG Quansheng;CHEN Feihu(Guangxi University of Chinese Medicine,Nanning Guangxi 530200,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning Guangxi 530023,China)

机构地区：[1]广西中医药大学研究生院,广西南宁530200 [2]广西中医药大学第一附属医院,广西南宁530023

出　　处：《广西师范大学学报（自然科学版）》2023年第4期25-32,共8页Journal of Guangxi Normal University:Natural Science Edition

基　　金：广西自然科学基金(2018GXNSFAA281119)。

摘　　要：骨质疏松症是一种全身性代谢性骨骼疾病,可导致骨量减少并由于微结构退化而增加骨折的风险。目前,西药治疗往往伴随有较为严重的不良反应,降低患者的依从性,从而影响治疗效果。中药具有不良反应小、多途径、多靶点的特点,在“肾主骨生髓”理论的指导下,发现骨碎补具有治疗骨质疏松症的作用。骨碎补总黄酮是骨碎补发挥抗骨质疏松作用的主要活性成分,随着中药药理学研究的不断深入,发现骨碎补总黄酮可以从多个环节调控骨性细胞的成骨增殖、分化、凋亡,促进骨形成,增加骨量,达到防治骨质疏松症的作用。涉及的信号通路包括Wnt/β-catenin信号通路、MAPK信号通路、OPG/RANKL/RANK信号通路、BMPs信号通路、PI3K/AKT/mTOR信号通路等。本文对近年来骨碎补总黄酮在防治骨质疏松方面的分子作用机制进行综述,探讨骨碎补总黄酮在体内抗骨质疏松作用的确切机制,为研究和开发抗骨质疏松新型药物研究提供理论依据。Osteoporosis is a systemic metabolic bone disease that can cause reduced bone mass and increase the risk of fracture due to microstructural degradation.At present,western medicine treatment is often accompanied by more serious adverse reactions,which reduce patients’compliance,thus affecting the treatment effect.Traditional Chinese medicine is characterized by small adverse reactions,multiple ways and multiple targets.Under the guidance of the theory of“the main kidney bone produces marrow”,it is found that Rhizoma drynariae repair has a role in treating osteoporosis.The total flavones of R.drynariae are the main active components of R.drynariae which play an anti-osteoporosis role.With the continuous in-depth study of the pharmacology of traditional Chinese medicine,the total flavones of R.drynariae can regulate the osteogenic proliferation,differentiation and apoptosis of bone cells from multiple links,promote bone formation,increase bone mass,and achieve the role of preventing and treating osteoporosis.The signaling pathways involved include Wnt/β-catenin signaling pathway,MAPK signaling pathway,OPG/RANKL/RANK signaling pathway,BMPs signaling pathway,PI3K/AKT/mTOR signaling pathway,etc.This article summarized the molecular mechanism of the total flavones of R.drynariae and its main active components in the prevention and treatment of osteoporosis in recent years,discussed the exact mechanism of the anti-osteoporosis effect of osteoporotic in vivo,and provided help for the research and development of new anti-osteoporosis drugs.

关 键 词：骨碎补 黄酮 活性单体 柚皮苷 柚皮素 骨质疏松症 分子机制 

分 类 号：R285[医药卫生—中药学]