生长抑素联合卡络磺钠在消化道出血治疗中的应用  

Application of Growth Inhibitor Combined with Carbazochrome Sodium Sulfonate in the Treatment of Gastrointestinal Bleeding

作　　者：赵斌 徐洁[1] ZHAO Bin;XU Jie(Department of Gastroenterology,Zhangjiagang First People's Hospital,Zhangjiagang,Jiangsu Province,215600 China)

机构地区：[1]张家港市第一人民医院消化内科,江苏张家港215600

出　　处：《系统医学》2023年第12期107-110,119,共5页Systems Medicine

摘　　要：目的分析生长抑素加卡络磺钠用于消化道出血治疗中的效果。方法选取2019年1月—2021年2月张家港市第一人民医院消化内科收治的消化道出血总共68例患者进行研究,根据随机数表法分成对照组(单纯卡络磺钠治疗)、观察组(在对照组基础上加以生长抑素治疗),各34例,比较两组疗效,止血及住院时间,治疗前后凝血酶原时间(prothrombin time,PT)、活化部分的凝血活酶时间(activated partial thromboplastin time,APTT)、血红蛋白(hemoglobin,Hb)与纤维蛋白原(fibrinogen,FIB)水平,并统计两组不良反应出现情况。结果观察组的有效率是97.06%,高于对照组的76.47%,差异有统计学意义(χ^(2)=4.610,P<0.05)。观察组的止血及住院时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组PT、APTT、Hb、FIB水平相比,差异无统计学意义(P>0.05);治疗后,两组PT、APTT均较前缩短,Hb及FIB均较前升高,且观察组PT、APTT均短于对照组,Hb及FIB水平均高于对照组,差异有统计学意义(P<0.05)。结论生长抑素加卡络磺钠用于消化道出血疗效确切,能迅速止血,改善患者的凝血功能,缩短其住院时间,且不会显著增加不良反应出现,安全性较高,值得采用。Objective To analyze the effect of growth inhibitor plus carbazochrome sodium sulfonate used in the treat⁃ment of gastrointestinal bleeding.Methods A total of 68 patients with gastrointestinal bleeding admitted to the Depart⁃ment of Gastroenterology of Zhangjiagang First People's Hospital from January 2019 to February 2021 were selected for the study.According to the method of randomized numerical table,they were divided into the control group(simple carbazochrome sodium sulfonate),the observation group(on the basis of the control group plus growth inhibitors),with 34 cases each.The efficacy,hemostasis and hospitalization time,prothrombin time(PT),activated partial thromboplas⁃tin time(APTT),hemoglobin(Hb)and fibrinogen(FIB)levels before and after the treatment were compared between the two groups,and the emergence of adverse reactions in the two groups were also counted.Results The effective rate of the observation group was 97.06%,higher than 76.47%of the control group,and the difference was statistically sig⁃nificant(χ^(2)=4.610,P<0.05).The hemostasis and hospitalization time of the observation group were shorter than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in PT,APTT,Hb and FIB levels between the two groups compared with each other(P>0.05).Af⁃ter treatment,PT and APTT of both groups were shorter than before,and Hb and FIB were higher than before,and the PT and APTT of the observation group were shorter than that of the control group,and the levels of Hb and FIB were higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion The efficacy of growth inhibitor plus carbazochrome sodium sulfonate in gastrointestinal hemorrhage is accurate,can rapidly stop bleeding,improve the coagulation function of patients,shorten the hospitalization time,and will not significantly in⁃crease the emergence of adverse reactions,with a high degree of safety,and it is w

关 键 词：生长抑素 卡络磺钠 消化道出血 凝血功能 

分 类 号：R4[医药卫生—临床医学]