光热响应性水凝胶组织工程移植物研究进展  

Research Progress of Photothermal Responsive Hydrogel Tissue Engineering

作　　者：高红霞 刘亚琼 张李玲 孙韶兰 管文超 王晓路 黄然 李贵才[1] GAO Hongxia;LIU Yaqiong;ZHANG Liling;SUN Shaolan;GUAN Wenchao;WANG Xiaolu;HUANG Ran;LI Guicai(Key Laboratory of Nerve Regeneration,Nantong University,Nantong 226001,China;Suzhou SIMATECH Co.,Ltd.,Suzhou 215168,China;Cathaya Holding Co.,Ltd.,Hangzhou 310004,China)

机构地区：[1]南通大学神经再生重点实验室,江苏南通226001 [2]苏州丝美特技术有限公司,江苏苏州215168 [3]凯喜雅控股有限公司,浙江杭州310004

出　　处：《中国材料进展》2023年第7期534-548,573,574,共17页Materials China

基　　金：国家自然科学基金项目(32171352);南通市“226”高层次人才培养项目(第二层次,2022II-276)。

摘　　要：组织工程是一个多学科交叉的领域,旨在除传统的创后/术后组织再生手段(自体移植、异体移植)外,利用现代技术设计和开发特定的生物材料,为组织损伤修复提供新的治疗思路。在组织工程应用的各种生物材料中,水凝胶由于其独特的生物相容性、力学可调性、可降解性、高度亲水性等性质,被广泛应用于生物医学工程领域。其中光热响应性水凝胶除了满足传统水凝胶的特性外,还具有温度可控、智能响应等优点,因此在组织工程、再生医学和药物缓释领域显示出很好的应用前景。然而,目前鲜有对光热响应性水凝胶作为组织工程移植物的系统性总结。概述了近几年来光热响应性水凝胶移植物的研究与发展,包括光热响应性水凝胶的历史背景和实际应用,总结了相关的研究成果并进行了讨论,最后提出了未来可能遇到的挑战并进行了展望,以期促进光热响应性水凝胶在组织工程领域的发展,供相关研究人员参考。Tissue engineering is a multidisciplinary field that aims to provide new therapeutic ideas using modern technologies to design and develop specific biomaterials in addition to the traditional means of post-traumatic/post-operative tissue regeneration(autologous transplantation,allografts).Among various biomaterials for tissue engineering applications,hydrogels are widely used in biomedical engineering due to their unique biocompatible,mechanically tunable,degradable and highly hydrophilic properties.Among them,photothermal responsive hydrogels have the advantages of temperature controllable and intelligent response in addition to the properties of traditional hydrogels,and thus show promising applications in the fields of tissue engineering,regenerative medicine and drug slow release.However,there are few systematic summaries of photothermal responsive hydrogels as tissue engineering grafts.This review provides an overview of the research and development of photothermal responsive hydrogel grafts in recent years,including the historical background of photothermal responsive hydrogels and practical applications,summarizes the relevant research results and discusses them,and finally presents possible challenges and outlooks in the future,with a view to promoting development of photothermal responsive hydrogels in the field of tissue engineering for the reference of related researchers.

关 键 词：组织工程 移植物 水凝胶 光热响应性 纳米材料 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]