季铵盐化N,N-二甲基-2-噁唑啉聚合物对表皮葡萄球菌的抗菌活性和生物相容性研究  

Antibacterial Activity of Quaternized Poly(N,N-dimethyl-2-oxazoline)Against Staphylococcus epidermis and Its Biocompatibility Study

作　　者：朱佶鹏 周敏 陈胜 江伟男 宋恭华[1] 刘润辉 ZHU Jipeng;ZHOU Min;CHEN Sheng;JIANG Weinan;SONG Gonghua;LIU Runhui(School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology,Shanghai 200237,China;School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;East China University of Science and Technology Shenzhen Research Institute,Shenzhen 518063,China)

机构地区：[1]华东理工大学药学院,上海200237 [2]华东理工大学超细材料制备与应用教育部重点实验室,上海200237 [3]华东理工大学材料科学与工程学院,上海200237 [4]华东理工大学深圳研究院,深圳518063

出　　处：《中国材料进展》2023年第7期575-581,574,共8页Materials China

基　　金：华东理工大学深圳研究院自由探索类基础研究项目(2021Szvup042)。

摘　　要：设计、合成了一系列聚合度不同的N,N-二甲基-2-噁唑啉聚合物,并用不同链长的烷基溴对聚合物进行季铵盐化。进一步对合成的季铵盐化的聚合物进行了表皮葡萄球菌的最低抑菌浓度、表皮葡萄球菌的最低杀菌浓度以及血红细胞溶血测试。实验结果表明,该聚合物对表皮葡萄球菌具有较好的抗菌活性,同时对血红细胞溶血率较低,展现出较好的选择性,在生物材料领域显示出较为广阔的应用前景。同时该季铵盐化的聚合物对多重耐药菌菌株的抗菌活性略高于对标准菌株的抗菌活性,显示了该类聚合物不仅能应用于抗普通表皮葡萄球菌,而且在抗多重耐药菌方面也有一定的应用潜力。A series of poly(N,N-dimethyl-2-oxazoline)with different degrees of polymerization were designed and synthesized.The polymers were quaternized with alkyl bromide of different chain lengths.The minimum inhibitory concentration,minimum bactericidal concentration against Staphylococcus epidermis and hemolysis test of the quaternized polymers were conducted.The results showed that the polymers have good antibacterial activity against Staphylococcus epidermis,and low hemolysis of the quaternized polymers to erythrocytes,showing its good selectivity and promising biomedical application.Moreover,the antibacterial activity of the polymers to multidrug-resistant strain is better than that of standard strain,which shows the potential of this kind of polymers in treating multidrug-resistant bacterial infection.

关 键 词：2-噁唑啉聚合物 抗菌 多重耐药菌 季铵盐 表皮葡萄球菌 

分 类 号：O631[理学—高分子化学]