可降解锌基合金在骨科领域的研究进展  

Research Progress on Biodegradable Zinc-Based Alloys in Orthopedics

作　　者：黄庆利 任伊宾 马玉豪 武夏鹏 HUANG Qingli;REN Yibin;MA Yuhao;WU Xiapeng(School of Materials Science and Engineering,Shenyang Ligong University,Shenyang 110159,China)

机构地区：[1]沈阳理工大学材料科学与工程学院,辽宁沈阳110159

出　　处：《中国材料进展》2023年第8期631-639,共9页Materials China

基　　金：辽宁省自然基金资助项目(2019-MS-267)。

摘　　要：进入21世纪以来,随着材料科学的进步,医用金属植入材料从传统的316L不锈钢、钛合金等惰性金属材料逐渐转向可降解金属材料。可降解金属材料由于其良好的生物相容性和适宜的降解速率,可以在完成植入任务时被人体吸收,无需二次手术将内植物取出,从而引起广泛关注。在过去的10多年里,镁和铁及其合金作为医用可降解金属被广泛研究。锌是人体所必需的营养元素之一,因具有良好的生物相容性和适宜的降解速率,锌基合金在最近几年里成为继镁基和铁基合金之后又一具有广泛应用前景的医用可降解金属。然而,对锌基合金的设计和制备等仍处于初步阶段,还有大量的研究工作需要完成。综述了生物降解锌近年来用于骨科领域的研究进展,重点讨论了锌及其合金的力学性能、生物降解性能和生物相容性以及锌的合金化和制造技术之间的关系。Since the beginning of the 21 st century,with the progress of materials science,medical metal implant materials have gradually changed from traditional inert metal materials such as 316L stainless steel and titanium alloy to degradable metal materials.Because of their good biocompatibility and suitable degradation rate,degradable metal materials can be absorbed by human body when they complete the implantation task,and no secondary surgery is needed to remove the implant,which has attracted wide attention.In the past decade,magnesium,iron and their alloys have been widely studied as medical degradable metals.Zinc is one of the essential nutrients for human body.Because of its good biocompatibility and suitable degradation rate,zinc-based alloy has become another widely used medical degradable metal in recent years after magnesium-based and iron-based alloys.However,the design and preparation of zinc-based alloys are still in the initial stage,and a lot of research works need to be completed.In this paper,the research progress of biodegradable zinc used in orthopedics in recent years was reviewed.The relationships between the mechanical properties,biodegradability and biocompatibility of zinc and its alloys and the alloying and manufacturing technology of zinc were discussed.

关 键 词：锌基合金 生物相容性 力学性能 骨科 可降解金属 

分 类 号：TG146.1[一般工业技术—材料科学与工程]