Proliferation-mediated asymmetric nanoencapsulation of singlecell and motility differentiation  

作　　者：WANG ShengLiang XU ZhiJun CHEN HaiXu WANG XiaoLiang LIN Song WANG Lei LIU XiaoMan HUANG Xin 

机构地区：[1]MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage,School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin 150001,China

出　　处：《Science China(Technological Sciences)》2023年第7期2134-2146,共13页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos.22171058 and 21871069);the Fundamental Research Funds for the Central Universities (Grant No.HIT.OCEF.2021027)。

摘　　要：The biointerface engineering of living cells by creating an abiotic shell has important implications for endowing cells with exogenous properties with improved cellular behavior,which then boosts the development of the emerging field of living cell hybrid materials.Herein,we develop a way to perform active nanoencapsulation of single cell,which then endows the encapsulated cells with motion ability that they do not inherently possess.The emerging motion characteristics of the encapsulated cells could be self-regulated in terms of both the motion velocity and orbits by different proliferation modes.Accordingly,by taking advantage of the emergence of differentiated moving abilities,we achieve the self-sorting between mother cells and daughter cells in a proliferated Saccharomyces cerevisiae cell community.Therefore,it is anticipated that our highlighted study could not only serve as a new technique in the field of single-cell biology analysis and sorting such as in studying the aging process in Saccharomyces cerevisiae,but also open up opportunities to manipulate cell functionality by creating biohybrid materials to fill the gap between biological systems and engineering abiotic materials.

关 键 词：biointerface engineering MICROMOTORS SELF-PROPULSION SELF-SORTING UREASE 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]