双孔钾通道TASK-1在心房颤动的研究进展  

Research progress of two-well potassium channel TASK-1 in atrial fibrillation

作　　者：徐健 张栋 马艺波 罗文平[1] 易甫 XU Jian;ZHANG Dong;MA Yi-bo;LUO Wen-ping;YI Fu(Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,Shaanxi,China;Department of Cardiology,First Affiliated Hospital,Air Force Medical University,Xi’an 710032,Shaanxi,China)

机构地区：[1]陕西中医药大学,陕西咸阳712000 [2]空军军医大学第一附属医院心脏内科,陕西西安710032

出　　处：《心脏杂志》2023年第3期350-354,共5页Chinese Heart Journal

基　　金：国家自然科学基金项目资助(81970274)。

摘　　要：心房颤动(atrial fibrillation,AF)是成人最常见的持续性心律失常,随着全球人口老龄化AF的发病率和患病率正在逐年上升。AF的临床治疗手段持续改进并不断优化,但房颤发病机制仍未完全阐明。双孔钾通道家族中的TWIK相关酸敏感钾通道1(TWIK-related acid-sensitive potassium channel 1,TASK-1),其可能为一有巨大价值的AF治疗靶点。本综述系统总结了关于双孔钾通道家族中TAKS-1通道与房颤的研究进展。Atrial Fibrillation(AF)is the most common persistent arrhythmia in adults.With the aging of the global population,the incidence and prevalence of AF are increasing year by year.The clinical treatment of AF continues to improve and optimize,but the pathogenesis of AF is still not fully elucidated.The TASK-1 channel in the two-well potassium channel family is specifically expressed in the atrium and affects the atrium cordis action potential duration(APD).The expression of Task-1 channel is up-regulated in AF patients,which may be a valuable therapeutic target for AF.This review systematically summarizes the research progress of TAKS-1 channel in two-pore potassium channel family and atrial fibrillation.

关 键 词：心房颤动 TASK-1 双孔钾通道 

分 类 号：R541.75[医药卫生—心血管疾病]