奥美沙坦酯联合氨氯地平治疗原发性高血压伴左心室肥厚的效果研究  

Effect of olmesartan medoxomil combined with amlodipine in the treatment of essential hypertension complicated by left ventricular hypertrophy

作　　者：邓先柱 冯文化[1] 周宇 王鹏翔 李如男 翁菲菲[1] 李强 Deng Xianzhu;Feng Wenhua;Zhou Yu;Wang Pengxiang;Li Runan;Weng Feifei;Li Qiang(Department of Cardiology,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院心内科,南阳473000

出　　处：《中国实用医刊》2023年第10期104-107,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析奥美沙坦酯联合氨氯地平治疗原发性高血压伴左心室肥厚的效果。方法抽取2020年2月至2022年2月南阳市中心医院收治的原发性高血压伴左心室肥厚患者104例,按随机数表法分为观察组与对照组,每组52例。对照组采用氨氯地平治疗,观察组在对照组基础上采用奥美沙坦酯治疗。比较两组治疗效果、血压[收缩压(SBP)、舒张压(DBP)]、左心室肥厚指标[左心室质量指数(LVMI)、左心室后壁厚度(LVPWT)、室间隔厚度(IVST)]、25-羟基维生素D[25-(OH)D]水平、同型半胱氨酸(Hcy)水平及不良反应发生率。结果观察组总有效率(96.15%,50/52)高于对照组(80.77%,42/52),P<0.05。治疗后,观察组SBP、DBP水平低于对照组(P<0.05)。治疗后,观察组LVMI低于对照组,LVPWT、IVST小于对照组(P<0.05)。治疗后,观察组25-(OH)D水平高于对照组,Hcy水平低于对照组(P<0.05)。观察组不良反应发生率(3.85%,2/52)低于对照组(15.38%,8/52),P<0.05。结论奥美沙坦酯联合氨氯地平治疗原发性高血压伴左心室肥厚的效果确切,可调节25-(OH)D、Hcy表达,降低血压,逆转左心室肥厚,并可降低不良反应发生率。Objective To analyze the effect of olmesartan medoxomil combined with amlodipine in the treatment of essential hypertension complicated by left ventricular hypertrophy.Methods A total of 104 patients with essential hypertension complicated by left ventricular hypertrophy who were treated in Nanyang Central Hospital from February 2020 to February 2022 were selected,and they were divided into observation group and control group according to random number table method,with 52 patients in each group.The control group was treated with amlodipine,and the observation group was treated with olmesartan medoxomil based on the treatment of the control group.The curative effect,blood pressure,including systolic blood pressure(SBP)and diastolic blood pressure(DBP),left ventricular hypertrophy indexes,including left ventricular mass index(LVMI),left ventricular posterior wall thickness(LVPWT)and interventricular septum thickness(IVST),level of 25-hydroxyvitamin D,referred to as 25-(OH)D,homocysteine(Hcy)level,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.15%(50/52),which was higher than the 80.77%(42/52)of the control group(P<0.05).After treatment,the levels of SBP and DBP in the observation group were lower than those in the control group(P<0.05).After treatment,LVMI,LVPWT and IVST in the observation group were lower than those in the control group(P<0.05).After treatment,the level of 25-(OH)D in the observation group was higher than that in the control group,and the level of Hcy was lower than that in the control group(P<0.05).The incidence of adverse reactions in the observation group(3.85%,2/52)was lower than that in the control group(15.38%,8/52),and the difference was statistically significant(P<0.05).Conclusions Olmesartan medoxomil combined with amlodipine is effective in the treatment of essential hypertension complicated by left ventricular hypertrophy.It can regulate the expression of 25-(OH)D and Hcy,reduce blood pressure,rev

关 键 词：原发性高血压 左心室肥厚 奥美沙坦酯 氨氯地平 

分 类 号：R544.11[医药卫生—心血管疾病]