水环境中磺胺类药物代谢产物的行为特征与生态毒理  

Behavioral and ecotoxicology of sulfonamide metabolites in the aquatic environment

作　　者：戴佳佳 宋金明[1,2,3,4] 李学刚 马骏[1,4] 袁华茂 段丽琴[1,2,3,4] 温丽联[1,2] 曲宝晓[1,2,3,4] 邢建伟 王启栋[1,2,3,4] DAI Jiajia;SONG Jinming;LI Xuegang;MA Jun;YUAN Huamao;DUAN Liqin;WEN Lilian;QU Bao-xiao;XING Jianwei;WANG Qidong(Key Laboratory of Marine Ecology and Environmental Sciences,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,Shandong,China;University of Chinese Academy of Sciences,Beijing 100049,China;Function Laboratory for Marine Ecology and Environmental Sciences,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,Shandong,China;Center for Ocean Mega-Science,Chinese Academy of Sciences,Qingdao 266071,Shandong,China)

机构地区：[1]中国科学院海洋研究所,中国科学院海洋生态与环境科学重点实验室,山东青岛266071 [2]中国科学院大学,北京100049 [3]青岛海洋科学与技术试点国家实验室,海洋生态与环境科学功能实验室,山东青岛266237 [4]中国科学院海洋大科学研究中心,山东青岛266071

出　　处：《应用生态学报》2023年第8期2274-2284,共11页Chinese Journal of Applied Ecology

基　　金：中国科学院特别研究助理资助项目;中国科学院A类先导专项项目(XDA23050501)资助。

摘　　要：磺胺类药物(SAs)作为最早应用的一类广谱合成抗菌剂,被广泛应用于人类医疗健康和兽医领域。进入体内的SAs大多以母体或代谢产物的形式排入水环境。SAs及其代谢产物在水环境中的残留以及产生的耐药性可能严重威胁生态系统和人类健康。本文在总结相关研究的基础上,归纳和分析了近年来有关SAs的研究成果,介绍了SAs的主要代谢产物类型、代谢产物在不同水环境中的分布特征等,讨论了SAs代谢产物的生态毒理,特别是磺胺类抗性基因(sul-ARGs)的分布及危害。最后对未来的研究工作进行了展望。本文可为SAs的进一步研究提供基础资料。Sulfonamides(SAs)are the first broad-spectrum synthetic antimicrobial agents used in human health and veterinary medicine.The majority of SAs entering human body is discharged into aquatic environment in the form of parent material or metabolites.The residues of SAs and their metabolites in the aquatic environment and the development of drug resistance can be serious threats to ecosystems and human health.We summarized recent advances in the research of SAs.The main metabolite types of SAs and the distribution characteristics of metabolites in different aquatic environments were introduced.The ecotoxicology of SAs metabolites,especially the distribution and hazards of sulfonamide resistance genes(sul-ARGs),were discussed with emphasis.Finally,the future research works were proposed.This paper could provide basic information for further research on SAs.

关 键 词：磺胺类药物代谢产物 水环境 生态毒理 磺胺类抗性基因(sul-ARGs) 

分 类 号：X52[环境科学与工程—环境工程]