MTHFR基因C677T位点和ACE基因插入/缺失基因型与老年高血压患者合并轻度认知障碍的关系  

Relationship between MTHFR Gene C677T Locus and ACE Gene Insertion/Deletion Genotype and Mild Cognitive Impairment in Elderly Patients with Hypertension

作　　者：张瑶 张毅[2] 陈芸[2] 郭洪波[3] 郭晓玲 车晓芳 ZHANG Yao;ZHANG Yi;CHEN Yun;GUO Hongbo;GUO Xiaoling;CHE Xiaofang(The First Clinical College of Medicine,Shanxi Medical University,Taiyuan 030000,China;Department of Gerontology,the First Hospital of Shanxi Medical University,Taiyuan 030000,China;Department of Traditional Chinese Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学第一临床医学院,山西省太原市030000 [2]山西医科大学第一医院老年病科,山西省太原市030000 [3]山西医科大学第一医院中医科,山西省太原市030000

出　　处：《实用心脑肺血管病杂志》2023年第9期12-15,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：山西省卫生健康委科研项目(2022040)。

摘　　要：目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T位点和血管紧张素转换酶(ACE)基因插入/缺失(I/D)基因型与老年高血压患者合并轻度认知障碍(MCI)的关系。方法选取2022年6月至2023年4月山西医科大学第一医院老年病科收治的老年高血压患者80例为研究对象,收集患者的临床资料,采用飞行时间质谱法检测MTHFR基因C677T位点、ACE基因I/D基因型。根据是否合并MCI将患者分为病例组和对照组。采用多因素Logistic回归分析探讨老年高血压患者合并MCI的影响因素。结果病例组43例,对照组37例。病例组同型半胱氨酸(Hcy)水平高于对照组(P<0.05)。两组MTHFR基因C677T位点、ACE基因I/D基因型比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,Hcy、MTHFR基因C677T位点TT基因型是老年高血压患者合并MCI的影响因素(P<0.05)。结论Hcy升高、MTHFR基因C677T位点TT基因型是老年高血压患者合并MCI的危险因素,尚未发现ACE基因I/D基因型与老年高血压患者合并MCI相关。Objective To investigate the relationship between methylenetetrahydrofolate reductase(MTHFR)gene C677T locus and angiotensin converting enzyme(ACE)gene insertion/deletion(I/D)genotype and mild cognitive impairment(MCI)in elderly patients with hypertension.Methods A total of 80 elderly hypertensive patients who admitted to the Department of Gerontology of the First Hospital of Shanxi Medical University from June 2022 to April 2023 were selected as the research objects.Clinical data of patients were collected,and the MTHFR gene C677T locus and ACE gene I/D genotype were detected using time of flight mass spectrometry.The patients were divided into case group and control group based on presence or absence of MCI.Multivariate Logistic regression analysis was used to analyze the influencing factors of MCI in elderly patients with hypertension.Results There were 43 cases in the case group and 37 cases in the control group.The homocysteine(Hcy)level in the case group was higher than that in the control group(P<0.05).There were significant differences in the MTHFR gene C677T locus and ACE gene I/D genotype between the two groups(P<0.05).Multivariate Logistic regression analysis showed that Hcy,MTHFR gene C677T locus TT genotype were the influencing factors of MCI in elderly patients with hypertension(P<0.05).Conclusion Elevated Hcy,MTHFR gene C677T locus TT genotype are risk factors for MCI in elderly patients with hypertension.No association was found between ACE gene I/D genotype and MCI in elderly patients with hypertension.

关 键 词：高血压 认知障碍 老年人 亚甲基四氢叶酸还原酶 血管紧张素转换酶 基因型 

分 类 号：R544.1[医药卫生—心血管疾病]