流行性感冒应用奥司他韦的效果及对患儿免疫功能及血清PCT、CRP水平的影响分析  

Analysis of effect of oseltamivir on influenza,and its influence on immune function,serum PCT and CRP levels in children

作　　者：王元敏[1] 韩秀华[1] 李春姬[1] WANG Yuan-min;HAN Xiu-hua;LI Chun-ji(Infection Department,Laiyang Central Hospital,Yantai 265200,China)

机构地区：[1]烟台市莱阳中心医院感染科,265200

出　　处：《中国实用医药》2023年第16期21-24,共4页China Practical Medicine

摘　　要：目的探究流行性感冒应用奥司他韦的效果及对患儿免疫功能及血清降钙素原(PCT)、C反应蛋白(CRP)水平的影响。方法100例流行性感冒患儿,采用随机数字表法分为观察组和对照组,各50例。对照组采用利巴韦林治疗,观察组采用奥司他韦治疗。比较两组临床疗效、免疫功能指标及血清PCT、CRP水平。结果观察组治疗总有效率为98.00%,高于对照组的84.00%,差异具有统计学意义(P<0.05)。治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且观察组CD3^(+)(64.17±6.53)%、CD4^(+)(44.59±6.29)%、CD4^(+)/CD8^(+)(1.45±0.31)均高于对照组的(61.32±5.15)%、(40.25±5.38)%、(1.21±0.26),差异具有统计学意义(P<0.05)。治疗后,两组血清PCT、CRP水平低于治疗前,且观察组血清PCT(0.10±0.02)μg/L、CRP(9.48±1.46)mg/L均低于对照组的(0.16±0.05)μg/L、(17.12±1.85)mg/L,差异具有统计学意义(P<0.05)。结论奥司他韦治疗流行性感冒患儿的疗效显著,可有效改善免疫功能,降低血清PCT、CRP水平。Objective To investigate the effect of oseltamivir on influenza,and its influence on immune function,serum procalcitonin(PCT)and C-reactive protein(CRP)levels in children.Methods A total of 100 children with influenza were divided into observation group and control group according to the random numerical table,with 50 cases in each group.The control group was treated with ribavirin,and the observation group with oseltamivir.The clinical efficacy,immune function indexes,serum PCT and CRP levels were compared between the two groups.Results The total effective rate of the observation group was 98.00%,which was higher than that of 84.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CD3^(+),+CD4^(+) and CD4^(+)/CD8^(+)in both groups were higher than those before treatment in this group;the observation group had CD3 of(64.17±6.53)%,CD4 of(44.59±6.29)%and CD4^(+)/CD8^(+)of(1.45±0.31),which were higher than those of(61.32±5.15)%,(40.25±5.38)%and(1.21±0.26)in the control group,and the differences were statistically significant(P<0.05).After treatment,the serum PCT and CRP levels in both groups were lower than those before treatment in this group;serum PCT of(0.10±0.02)μg/L and CRP of(9.48±1.46)mg/L in the observation group were lower than those of(0.16±0.05)μg/L and(17.12±1.85)mg/L in the control group;the differences were statistically significant(P<0.05).Conclusion Oseltamivir is effective in the treatment of children with influenza,which can effectively improve the immune function and reduce the levels of serum PCT and CRP.

关 键 词：奥司他韦 流行性感冒 免疫功能 降钙素原 C反应蛋白 

分 类 号：R725.1[医药卫生—儿科]