小麦纤维素联合布拉氏酵母菌散剂治疗小儿功能性便秘的疗效及对患儿血清指标的影响分析  

Analysis of the efficacy of fiberform combined with saccharomyces boulardii sachets in the treatment of pediatric functional constipation and its influence on the serum indexes of children

作　　者：邹莉[1] 宫晓丽 ZOU Li;GONG Xiao-li(Second Weihai Municipal Hospital Affiliated to Qingdao University,Weihai 264200,China)

机构地区：[1]青岛大学附属威海市立第二医院,264200

出　　处：《中国实用医药》2023年第16期39-43,共5页China Practical Medicine

摘　　要：目的分析小麦纤维素联合布拉氏酵母菌散剂治疗小儿功能性便秘的疗效及对患儿血清指标的影响。方法前瞻性随机选取77例小儿功能性便秘患儿,以电脑随机形式分为对照组(38例)和治疗组(39例)。对照组应用布拉氏酵母菌散剂进行治疗,治疗组在对照组基础上联合小麦纤维素治疗。比较两组患者治疗前后便秘症状(排便次数、排便不尽、排便困难、排便疼痛)评分、血清指标(胃动素、胃泌素、P物质、生长抑素)、胃肠功能(直肠最大容量感觉阈值、直肠静息压、肛门静息压、模拟排便时肛管压、肛管最大收缩压)、营养状态(体质量指数、尿液淀粉酶、氮平衡、转铁蛋白、血清蛋白)及临床疗效。结果治疗后,两组患儿排便次数、排便不尽、排便困难、排便疼痛评分均低于本组治疗前,且治疗组患儿排便次数评分(0.57±0.15)分、排便不尽评分(0.63±0.12)分、排便困难评分(0.79±0.20)分、排便疼痛评分(0.70±0.11)分均低于对照组的(1.82±0.62)、(1.39±0.76)、(1.87±0.71)、(1.21±0.63)分,差异均具有统计学意义(P<0.05)。治疗后,两组患儿胃动素、胃泌素、P物质高于本组治疗前,生长抑素低于本组治疗前,且治疗组患儿胃动素(237.36±49.13)ng/L、胃泌素(33.55±5.17)ng/L、P物质(28.73±11.16)ng/L均高于对照组的(213.38±45.17)、(30.56±5.57)、(16.91±11.25)ng/L,生长抑素(12.31±3.09)ng/L低于对照组的(16.62±5.51)ng/L,差异均具有统计学意义(P<0.05)。治疗后,两组患儿直肠最大容量感觉阈值、直肠静息压、肛门静息压、模拟排便时肛管压、肛管最大收缩压均低于本组治疗前,且治疗组患儿直肠最大容量感觉阈值(132.01±19.32)ml、直肠静息压(8.57±1.56)mm Hg(1 mm Hg=0.133 kPa)、肛门静息压(23.58±2.97)mm Hg、模拟排便时肛管压(21.05±5.45)mm Hg、肛管最大收缩压(132.21±19.96)mm Hg均低于对照组的(150.65±20.31)ml、(9.41±1.33)mm Hg、(27.40±2Objective To analyze the efficacy of fiberform combined with saccharomyces boulardii sachets in the treatment of pediatric functional constipation and its influence on the serum indexes of children.Methods A total of 77 children with functional constipation were randomly divided into control group(38 cases)and treatment group(39 cases).The control group was treated with saccharomyces boulardii sachets,and the treatment group was combined with fiberform on the basis of the control group.Both groups were compared in terms of scores of constipation symptoms(frequency of defecation,incomplete defecation,difficult defecation,painful defecation),serum indexes(motilin,gastrin,substance P,somatostatin),gastrointestinal function(rectal maximum volume of sensory threshold,rectal resting pressure,anal resting pressure,anal canal pressure during simulated defecation,anal canal maximum systolic pressure),nutritional status(body mass index,urinary amylase,nitrogen balance,transferrin,serum protein),and clinical efficacy.Results After treatment,the scores of frequency of defecation,incomplete defecation,difficult defecation,painful defecation in both groups were lower that those before treatment in this group;in the treatment group,the score of frequency of defecation was(0.57±0.15)points,the score of incomplete defecation was(0.63±0.12)points,the score of difficult defecation was(0.79±0.20)points,and the score of painful defecation was(0.70±0.11)points,which were lower than those of(1.82±0.62),(1.39±0.76),(1.87±0.71),and(1.21±0.63)points in the control group;the differences were statistically significant(P<0.05).After treatment,the motilin and gastrin in both groups were higher than those before treatment in this group,and somatostatin was lower than that before treatment in this group;in the treatment group,the motilin was(237.36±49.13)ng/L,the gastrin was(33.55±5.17)ng/L,and the substance P was(28.73±11.16)ng/L,which were higher than those of(213.38±45.17),(30.56±5.57),and(16.91±11.25)ng/L in the control group;

关 键 词：小麦纤维素 布拉氏酵母菌散剂 小儿功能性便秘 

分 类 号：R725.7[医药卫生—儿科]