肺泡-动脉氧分压差在新生儿呼吸窘迫综合征中的应用价值分析  

Application value of alveolar arterial oxygen pressure difference in neonatal respiratory distress syndrome

作　　者：罗丹 薛凤莲 陈晓东 LUO Dan;XUE Feng-lian;CHEN Xiao-dong(Department of Pediatrics,Shantou Maternal and Child Health Hospital,Shantou 515100,China)

机构地区：[1]汕头市妇幼保健院儿科,515100 [2]霞浦福宁医院儿科,515100 [3]民生医院新生儿科,515100

出　　处：《中国实用医药》2023年第16期47-50,共4页China Practical Medicine

摘　　要：目的探讨肺泡-动脉氧分压差(A-aDO_(2))在新生儿呼吸窘迫综合征(NRDS)中的应用价值。方法选取46例NRDS患儿为观察组,另选取同期健康新生儿46例为对照组。比较两组胎龄和动脉血气指标[A-aDO_(2)、氧合指数(OI)、呼吸指数(RI)],比较观察组患儿不同时间点的动脉血气指标,统计观察组患儿撤机后的预后情况,比较观察组撤机后生存和死亡患儿的动脉血气指标。结果观察组的胎龄(30.00±1.00)周小于对照组的(34.00±1.00)周,A-aDO_(2)(45.68±13.42)mm Hg(1 mm Hg=0.133 kPa)、RI(5.22±0.86)高于对照组的(18.65±1.56)mm Hg、(0.78±0.28),OI(178.63±8.47)mm Hg低于对照组的(330.64±7.56)mm Hg,差异具有统计学意义(P<0.05)。观察组患儿机械通气前、机械通气2 d后、撤机前的A-aDO_(2)、OI、RI比较,差异具有统计学意义(P<0.05);且机械通气前、机械通气2 d后、撤机前A-aDO_(2)、RI依次降低,OI依次升高,差异具有统计学意义(P<0.05)。观察组患儿撤机后生存41例,死亡5例。观察组撤机后生存患儿的A-aDO_(2)(20.58±10.45)mm Hg、RI(1.15±0.13)低于死亡患儿的(46.50±8.56)mm Hg、(4.58±0.28),OI(389.36±5.64)mm Hg高于死亡患儿的(175.44±7.56)mm Hg,差异具有统计学意义(P<0.05)。结论A-aDO_(2)可评估NRDS患儿的病情,能作为诊断和判断预后的指标。Objective To discuss the application value of alveolar arterial oxygen pressure difference(A-aDO_(2))in neonatal respiratory distress syndrome(NRDS).Methods 46 children with NRDS were selected as the observation group,and another 46 healthy neonates at the same period were selected as the control group.The gestational age and arterial blood gas indexes[A-aDO_(2),oxygenation index(OI),respiratory index(RI)]were compared between the two groups;the arterial blood gas indexes of the children in the observation group at different time points were compared;the prognosis of the children in the observation group after weaning was counted;the arterial blood gas indexes of the children who survived and died after weaning were compared in the observation group.Results The gestational age of(30.00±1.00)weeks in the observation group was less than that of(34.00±1.00)weeks in the control group;A-aDO_(2) of(45.68±13.42)mm Hg(1 mm Hg=0.133 kPa)and RI of(5.22±0.86)in the observation group were higher than those of(18.65±1.56)mm Hg and(0.78±0.28)in the control group;OI of(178.63±8.47)mm Hg in the observation group was lower than that of(330.64±7.56)mm Hg in the control group;the differences were statistically significant(P<0.05).There were statistically significant differences in A-aDO_(2),OI and RI before mechanical ventilation,2 d after mechanical ventilation and before weaning in the observation group(P<0.05).In addition,A-aDO_(2) and RI decreased and OI increased successively before mechanical ventilation,2 d after mechanical ventilation and before weaning,and the differences were statistically significant(P<0.05).In the observation group,41 children survived and 5 children died after weaning.In the observation group,A-aDO_(2) of(20.58±10.45)mm Hg and RI of(1.15±0.13)of surviving children were lower than those of(46.50±8.56)mm Hg and (4.58±0.28)of dead children;OI of(389.36±5.64)mm Hg of surviving children was higher than that of(175.44±7.56)mm Hg of dead children;the differences were statistically significant(P<

关 键 词：新生儿呼吸窘迫综合征 肺泡-动脉氧分压差 应用价值 

分 类 号：R722.1[医药卫生—儿科]